{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T12:08:08Z","timestamp":1788782888044,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T00:00:00Z","timestamp":1496361600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The purpose of this study was to investigate the safety and feasibility of autologous adipose\u2010derived regenerative cells (<jats:styled-content style=\"fixed-case\">ADRC<\/jats:styled-content>) in the treatment of chronic anal fissure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A prospective pilot study was conducted in six patients with chronic anal fissures at the First Surgical Clinic, Clinical Center of Serbia and at the BelPrime Clinic, Belgrade, Serbia. All patients were candidates for surgical treatment. The average duration of symptoms was 24\u00a0months. Pain assessment was quantified using a visual analogue scale and bowel continence was assessed using the Wexner incontinence score. Both were assessed before treatment and during each postoperative outpatient visit. Liposuction was performed under local or general anaesthesia. Extraction of <jats:styled-content style=\"fixed-case\">ADRC<\/jats:styled-content> was achieved with a closed automated medical device. The fat and <jats:styled-content style=\"fixed-case\">ADRC<\/jats:styled-content> were injected subcutaneously into the edge of the fissure. The rest of the pellet was infiltrated into the internal anal sphincter. The study has been registered at ClinicalTrials.gov (<jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>02628522).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Complete healing of the anal fissure and the disappearance of symptoms was achieved in all patients. The average time to complete pain cessation was 33.7\u00a0\u00b1\u00a015.0\u00a0days. All fissures healed after 3\u00a0months and remained healed 12\u00a0months after the procedure. There were no complications related to the procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The application of <jats:styled-content style=\"fixed-case\">ADRC<\/jats:styled-content> may be an alternative to lateral sphincterotomy and a reliable procedure which avoids faecal incontinence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.13555","type":"journal-article","created":{"date-parts":[[2016,11,5]],"date-time":"2016-11-05T13:59:26Z","timestamp":1478354366000},"page":"570-575","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["A novel method for treatment of chronic anal fissure: adipose\u2010derived regenerative cells \u2013 a pilot study"],"prefix":"10.1111","volume":"19","author":[{"given":"K.","family":"Andjelkov","sequence":"first","affiliation":[{"name":"BelPrime Clinic Belgrade Serbia"},{"name":"SESA University Ponte Nova 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