{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T22:02:40Z","timestamp":1764540160869},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,5,4]],"date-time":"2017-05-04T00:00:00Z","timestamp":1493856000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study assessed the effectiveness of sacral neuromodulation (<jats:styled-content style=\"fixed-case\">SNM<\/jats:styled-content>) for faecal incontinence (<jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content>) following proctectomy with colorectal or coloanal anastomosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An Institutional Review Board (<jats:styled-content style=\"fixed-case\">IRB<\/jats:styled-content>)\u2010approved database identified patients treated for <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content> following proctectomy (<jats:styled-content style=\"fixed-case\">SNM<\/jats:styled-content>\u2010P) for benign or malignant disease, who were matched 1:1 according to preoperative Cleveland Clinic Florida Faecal Incontinence Scores (<jats:styled-content style=\"fixed-case\">CCF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">FIS<\/jats:styled-content>) with patients without proctectomy (<jats:styled-content style=\"fixed-case\">SNM<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>). Primary outcome was change in <jats:styled-content style=\"fixed-case\">CCF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">FIS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve patients (seven women) were in the <jats:styled-content style=\"fixed-case\">SNM<\/jats:styled-content>\u2010P group and 12 (all women) were in the <jats:styled-content style=\"fixed-case\">SNM<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> group. In the <jats:styled-content style=\"fixed-case\">SNM<\/jats:styled-content>\u2010P group, six patients underwent proctectomy for low rectal cancer and five received neoadjuvant chemoradiation. Five patients had handsewn anastomosis, and one had stapled coloanal anastomosis. One lead explantation occurred after a failed 2\u2010week <jats:styled-content style=\"fixed-case\">SNM<\/jats:styled-content> percutaneous trial. Six patients underwent proctectomy for benign conditions. Within\u2010group analyses revealed significant improvement in <jats:styled-content style=\"fixed-case\">CCF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">FIS<\/jats:styled-content> in the <jats:styled-content style=\"fixed-case\">SNM<\/jats:styled-content>\u2010P group (reduction from a score of 18 to a score of 14; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.02), which was more profound for benign disease (reduction from 14.5 to 8.5) than for rectal cancer (reduction from 19.5 to 15). <jats:styled-content style=\"fixed-case\">SNM<\/jats:styled-content> was explanted in 66% and 33% of patients after proctectomy for malignant and benign conditions, respectively. In the <jats:styled-content style=\"fixed-case\">SNM<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> group, 41% underwent overlapping sphincteroplasty. One patient received chemoradiation for anal cancer. Within\u2010group analysis for the <jats:styled-content style=\"fixed-case\">SNM<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> group showed significant improvement in <jats:styled-content style=\"fixed-case\">CCF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">FIS<\/jats:styled-content> (a reduction from 17.5 to 4.0; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.003). There was significant improvement in <jats:styled-content style=\"fixed-case\">CCF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">FIS<\/jats:styled-content> in patients without previous proctectomy (mean delta <jats:styled-content style=\"fixed-case\">CCF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">FIS<\/jats:styled-content>: 11.1 <jats:italic>vs<\/jats:italic> 4.7; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.011). Analysis of covariance (<jats:styled-content style=\"fixed-case\">ANCOVA<\/jats:styled-content>) reaffirmed that controls outperformed proctectomy patients (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.006).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">SNM<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content> after proctectomy appears less effective than <jats:styled-content style=\"fixed-case\">SNM<\/jats:styled-content> in patients without proctectomy, with high device explantation rates, particularly after neoadjuvant chemoradiation and proctectomy for low rectal cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.13570","type":"journal-article","created":{"date-parts":[[2016,11,25]],"date-time":"2016-11-25T07:17:22Z","timestamp":1480058242000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Sacral neuromodulation for the treatment of faecal incontinence following proctectomy"],"prefix":"10.1111","volume":"19","author":[{"given":"I.","family":"Mizrahi","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery Cleveland Clinic Florida Weston Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. A.","family":"Chadi","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Cleveland Clinic Florida Weston Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Haim","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Cleveland Clinic Florida Weston Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. R.","family":"Sands","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Cleveland Clinic Florida Weston Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Gurland","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Cleveland Clinic Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Zutshi","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Cleveland Clinic Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. D.","family":"Wexner","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Cleveland Clinic Florida Weston Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Cleveland Clinic Florida Weston Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2009.02066.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-1318.2003.t01-1-00503.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003840050086"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800790206"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.12968"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2012.02956.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e318221a934"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15999-0"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181cf8ed0"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-007-9103-5"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-013-1687-8"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-012-0823-8"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-0884-5"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-004-0729-7"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-008-0485-z"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-002-0412-9"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02050307"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000505"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-014-1207-z"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-015-2927-y"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318195e17c"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clcc.2014.12.007"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9223"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2008.2"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.14.779"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-005-0296-1"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.13570","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.13570","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.13570","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T14:09:43Z","timestamp":1696255783000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.13570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/codi.13570"],"URL":"https:\/\/doi.org\/10.1111\/codi.13570","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"2016-07-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}