{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:51:01Z","timestamp":1791352261787,"version":"4.3.1"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T00:00:00Z","timestamp":1499299200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007773","name":"Danone","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007773","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003142","name":"Fonds NutsOhra","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003142","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006628","name":"Mead Johnson Nutrition","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006628","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007723","name":"Takeda Pharmaceuticals U.S.A.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007723","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2017,7]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n \n Anastomotic leakage (\n AL<\/jats:styled-content>\n ) following abdominal surgery is a critical determinant of postoperative recovery, of which the aetiology is largely unknown. Interestingly, interventions aimed at reducing the inflammatory response and postoperative ileus (\n POI<\/jats:styled-content>\n ) have an unexpected effect on\n AL<\/jats:styled-content>\n . The aim of this study was to investigate the relation of\n POI<\/jats:styled-content>\n with inflammation and\n AL<\/jats:styled-content>\n after colorectal resection.\n <\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n \n A\n post hoc<\/jats:italic>\n analysis of a prospective randomized controlled trial in which patients underwent a colorectal resection was performed. Patients undergoing a colorectal resection were stratified into having or not having\n POI<\/jats:styled-content>\n . The incidence of\n AL<\/jats:styled-content>\n and other clinical parameters was registered prospectively. Intestinal fatty acid binding protein (I\u2010\n FABP<\/jats:styled-content>\n , a marker for tissue damage) and the inflammatory response in plasma and colon tissue were determined.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n AL<\/jats:styled-content>\n was present in nine of 43 patients in the\n POI<\/jats:styled-content>\n group, and in one of 65 in the group without\n POI<\/jats:styled-content>\n (\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.001). There was a significant association between\n POI<\/jats:styled-content>\n and\n AL<\/jats:styled-content>\n (\n OR<\/jats:styled-content>\n 12.57, 95%\n CI<\/jats:styled-content>\n : 2.73\u2013120.65;\n P\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.0005). Patients with\n POI<\/jats:styled-content>\n had significantly higher plasma levels of soluble tumour necrosis factor receptor 1 (\n TNFRSF<\/jats:styled-content>\n 1A) at 4\u00a0h postoperatively (0.89\u00a0ng\/l, interquartile range 0.56) than patients without\n POI<\/jats:styled-content>\n (0.80\u00a0ng\/l, interquartile range 0.37;\n P\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.04) and higher plasma levels of C\u2010reactive protein on the second day postoperatively (234\u00a0\u00b1\u00a077\n vs<\/jats:italic>\n 163\u00a0\u00b1\u00a086\u00a0mg\/l;\n P\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.001). Patients who developed\n AL<\/jats:styled-content>\n had significantly higher plasma levels of I\u2010\n FABP<\/jats:styled-content>\n compared with patients without\n AL<\/jats:styled-content>\n at 24\u00a0h after onset of surgery.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n POI<\/jats:styled-content>\n is associated with a higher prevalence of\n AL<\/jats:styled-content>\n and an increased inflammatory response.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/codi.13582","type":"journal-article","created":{"date-parts":[[2016,12,10]],"date-time":"2016-12-10T09:13:14Z","timestamp":1481361194000},"page":"667-674","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Relation between postoperative ileus and anastomotic leakage after colorectal resection: a\n post hoc<\/i>\n analysis of a prospective randomized controlled trial"],"prefix":"10.1111","volume":"19","author":[{"given":"E. G.","family":"Peters","sequence":"first","affiliation":[{"name":"Department of Surgery Catharina Hospital Eindhoven The Netherlands"},{"name":"Tytgat Institute for Liver and Intestinal Research Department of Gastroenterology Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Dekkers","sequence":"additional","affiliation":[{"name":"Department of Surgery Catharina Hospital Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. W.","family":"van Leeuwen\u2010Hilbers","sequence":"additional","affiliation":[{"name":"Tytgat Institute for Liver and Intestinal Research Department of Gastroenterology Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Daams","sequence":"additional","affiliation":[{"name":"Department of Surgery VU Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. W. E.","family":"Hulsew\u00e9","sequence":"additional","affiliation":[{"name":"Department of Surgery Zuyderland Medical Center Sittard\u2010Geleen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. J.","family":"de Jonge","sequence":"additional","affiliation":[{"name":"Tytgat Institute for Liver and Intestinal Research Department of Gastroenterology Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. A.","family":"Buurman","sequence":"additional","affiliation":[{"name":"Institute MHeNS Maastricht University Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. D. 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