{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T07:54:52Z","timestamp":1788508492735,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T00:00:00Z","timestamp":1496361600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Several modifiable and nonmodifiable health\u2010related behaviours are associated with the incidence of colorectal cancer (<jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>), but there is little research on their association with survival. This work aimed to investigate possible relationships between modifiable behavioural factors and outcomes on a study cohort of <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> patients undergoing potentially curative surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A retrospective cohort study was carried out of patients diagnosed with nonmetastatic <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> residing in the <jats:styled-content style=\"fixed-case\">NHS<\/jats:styled-content> Greater Glasgow and Clyde area, <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> and undergoing elective curative surgery (January 2011 to December 2012). Data were obtained from the Scottish Cancer Registry, National Scottish Death Records. Preoperative assessment of smoking, alcohol consumption, nurse\u2010measured body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) and exercise levels were recorded, and patients were followed until death or censorship. Survival analysis was carried out and proportional hazards assumptions were assessed graphically using plots and were then formally tested using the PHTEST procedure in <jats:sc>stata<\/jats:sc>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Of the initial 527 patients, 181 (34%) satisfied the inclusion criteria. The total duration of follow\u2010up was 480 person\u2010years. At the preoperative assessment, 75% of patients were overweight or obese, 10.6% were current smokers, 13.1% recorded excess alcohol consumption and 8.5% had physical difficulty climbing stairs. Age, <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>, histopathological stage and physical capacity all independently affected survival (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Overweight patients [hazard ratio (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) 2.81] and those who had difficulty climbing stairs (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 3.31) had a significantly poorer survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study found evidence that preoperative exercise capacity and <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> are important independent prognostic factors of survival in patients undergoing curative surgery for <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.13594","type":"journal-article","created":{"date-parts":[[2016,12,27]],"date-time":"2016-12-27T19:13:33Z","timestamp":1482866013000},"page":"544-550","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A retrospective cohort study of the influence of lifestyle factors on the survival of patients undergoing surgery for colorectal cancer"],"prefix":"10.1111","volume":"19","author":[{"given":"D.","family":"Alexander","sequence":"first","affiliation":[{"name":"University of Glasgow Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. M.","family":"Allardice","sequence":"additional","affiliation":[{"name":"West of Scotland Cancer Surveillance Unit University of Glasgow Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. J.","family":"Moug","sequence":"additional","affiliation":[{"name":"Department of Surgery Royal Alexandra Hospital Paisley UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. S.","family":"Morrison","sequence":"additional","affiliation":[{"name":"West of Scotland Cancer Surveillance Unit University of Glasgow Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,2]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Food, Nutrition, Physical Activity, and the Prevention of Cancer: A Global Perspective","author":"World Cancer Research Fund\/American Institute for Cancer Research","year":"2007"},{"key":"e_1_2_9_3_1","unstructured":"Cancer Research UK.Bowel cancer mortality statistics. Last updated: 22\/01\/2014.http:\/\/www.cancerresearchuk.org\/health-professional\/cancer-statistics\/statistics-by-cancer-type\/bowel-cancer(accessed September 2015)."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1242458"},{"key":"e_1_2_9_5_1","unstructured":"NHS National Services Scotland.Information services division Scotland; cancer statistics: colorectal cancer 2010.http:\/\/www.isdscotland.org\/Health-Topics\/Cancer\/Cancer-Statistics\/Colorectal\/(accessed April 2014)."},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.7799"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.310"},{"key":"e_1_2_9_8_1","volume-title":"International Statistical Classification of Diseases and Related Health Problems","year":"2010"},{"key":"e_1_2_9_9_1","unstructured":"The Scottish government: scottish index of multiple deprivation: 2009 general report.2009.http:\/\/www.gov.scot\/Topics\/Statistics\/SIMD(accessed September 2015)."},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.289"},{"key":"e_1_2_9_11_1","unstructured":"World Health Organisation: global database on body mass index.2006.http:\/\/apps.who.int\/bmi\/index.jsp?introPage%3Dintro_3.html(accessed September 2015)."},{"key":"e_1_2_9_12_1","unstructured":"The Scottish government: alcohol.2013.http:\/\/www.healthscotland.com\/scotlands-health\/evaluation\/planning\/MESAS\/Publications.aspx(accessed September 2015)."},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70378-9"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.29005"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj442"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.45.9735"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.068189"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-012-0071-2"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.20.2479"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2354.2003.00437.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23455"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.2010.127555"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-2959-9"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.56.3.167"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2003.12.006"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.0855"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.7.754"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g1823"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-003706"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.13594","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.13594","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.13594","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T13:47:58Z","timestamp":1696340878000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.13594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1111\/codi.13594"],"URL":"https:\/\/doi.org\/10.1111\/codi.13594","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"2016-06-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}