{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:43:53Z","timestamp":1760550233660,"version":"3.37.3"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T00:00:00Z","timestamp":1496361600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>In patients with rectal cancer, surgery and chemoradiotherapy may affect anal sphincter function. Few studies have evaluated anorectal function after neoadjuvant chemoradiotherapy (n\u2010CRT) and\/or transanal endoscopic microsurgery (TEM). The aim of this study was to evaluate the effects of n\u2010CRT and TEM on anorectal function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Thirty\u2010seven patients with rectal cancer underwent anorectal manometry and Wexner scoring for faecal incontinence at baseline, after n\u2010CRT (cT2\u2010T3N0 cancer) and at 4 and 12\u00a0months after surgery. Water\u2010perfused manometry measured anal tone at rest and during squeezing, rectal sensitivity and compliance. Twenty\u2010seven and 10 patients, respectively, underwent TEM without (Group A) or with n\u2010CRT (Group B).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In Group A, anal resting pressure decreased from 68\u00a0\u00b1\u00a023 to 54\u00a0\u00b1\u00a026\u00a0mmHg at 4\u00a0months (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.04) and improved 12\u00a0months after surgery (60\u00a0\u00b1\u00a030\u00a0mmHg). The Wexner score showed a significant increase in gas incontinence (59%), soiling (44%) and urgency (37%) rates at 4\u00a0months, followed by clinical improvement at 1\u00a0year (41%, 26% and 18%, respectively). In group B, anal resting pressure decreased from 65\u00a0\u00b1\u00a023 to 50\u00a0\u00b1\u00a018\u00a0mmHg at 4\u00a0months but remained stable at 12\u00a0months (44\u00a0\u00b1\u00a011\u00a0mmHg, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.02 <jats:italic>vs<\/jats:italic> preoperative values \u2013 no significant difference compared with evaluation at 4\u00a0months). Gas incontinence, soiling and urgency were observed in 50%, 50%, 25% and in 38%, 12% and 12% of cases, respectively, 4 and 12\u00a0months after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TEM does not significantly affect anal function. Instead, n\u2010CRT does affect anal function but without causing major anal incontinence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.13656","type":"journal-article","created":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T11:02:38Z","timestamp":1489748558000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Anal function after endoluminal locoregional resection by transanal endoscopic microsurgery and radiotherapy for rectal cancer"],"prefix":"10.1111","volume":"19","author":[{"given":"I.","family":"Biviano","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Medical Specialties Sapienza University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0182-8761","authenticated-orcid":false,"given":"A.","family":"Balla","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Surgical Specialties \u2018Paride Stefanini\u2019 Sapienza University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Badiali","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Specialties Sapienza University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Quaresima","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Surgical Specialties \u2018Paride Stefanini\u2019 Sapienza University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"D'Ambrosio","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Surgical Specialties \u2018Paride Stefanini\u2019 Sapienza University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Lezoche","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Surgical Specialties \u2018Paride Stefanini\u2019 Sapienza University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Corazziari","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Specialties Sapienza University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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