{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T23:52:27Z","timestamp":1746489147719},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,5,4]],"date-time":"2017-05-04T00:00:00Z","timestamp":1493856000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["11\/RFP\/3115"],"award-info":[{"award-number":["11\/RFP\/3115"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim was to develop a behavioural animal model of faecal continence and assess the effect of retro\u2010uterine balloon inflation (<jats:styled-content style=\"fixed-case\">RBI<\/jats:styled-content>) injury. <jats:styled-content style=\"fixed-case\">RBI<\/jats:styled-content> in the rat causes pudendal neuropathy, a risk factor for obstetric related faecal incontinence in humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Video\u2010tracking of healthy rats (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>12) in a cage containing a latrine box was used to monitor their defaecatory behaviour index (<jats:styled-content style=\"fixed-case\">DBI<\/jats:styled-content>) over 2\u00a0weeks. The <jats:styled-content style=\"fixed-case\">DBI<\/jats:styled-content> (range 0\u20131) was devised by dividing the defaecation rate (pellets per hour) outside the latrine by that of the whole cage. A score of 0 indicates all pellets were deposited in the latrine. Subsequently, the effects of <jats:styled-content style=\"fixed-case\">RBI<\/jats:styled-content> (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>19), sham surgery (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>4) and colostomy (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>2) were determined by monitoring the <jats:styled-content style=\"fixed-case\">DBI<\/jats:styled-content> for 2\u00a0weeks preoperatively and 3\u00a0weeks postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">DBI<\/jats:styled-content> for healthy rats was 0.1\u00a0\u00b1\u00a00.03 with no significant change over 2\u00a0weeks (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.71). In the <jats:styled-content style=\"fixed-case\">RBI<\/jats:styled-content> group, 13 of 19 rats (68%) showed no significant change in <jats:styled-content style=\"fixed-case\">DBI<\/jats:styled-content> postoperatively (0.08\u00a0\u00b1\u00a0 \u22120.05 <jats:italic>vs<\/jats:italic> 0.11\u00a0\u00b1\u00a0 \u22120.07) while in six rats the <jats:styled-content style=\"fixed-case\">DBI<\/jats:styled-content> increased from 0.16\u00a0\u00b1\u00a0 \u22120.09 to 0.46\u00a0\u00b1\u00a00.23. The negative control, sham surgery, did not significantly affect the <jats:styled-content style=\"fixed-case\">DBI<\/jats:styled-content> (0.09\u00a0\u00b1\u00a00.06 <jats:italic>vs<\/jats:italic> 0.08\u00a0\u00b1\u00a00.04, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.14). The positive control, colostomy, increased the <jats:styled-content style=\"fixed-case\">DBI<\/jats:styled-content> from 0.26\u00a0\u00b1\u00a00.03 to 0.86\u00a0\u00b1\u00a00.08.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the first study showing a quantifiable change in defaecatory behaviour following injury in an animal model. This model of pudendal neuropathy affects continence in 32% of rats and provides a basis for research on interventions for incontinence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.13664","type":"journal-article","created":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T14:12:38Z","timestamp":1490019158000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Altered defaecatory behaviour and faecal incontinence in a video\u2010tracked animal model of pudendal neuropathy"],"prefix":"10.1111","volume":"19","author":[{"given":"L. A.","family":"Devane","sequence":"first","affiliation":[{"name":"School of Medicine and Medical Science University College Dublin Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Lucking","sequence":"additional","affiliation":[{"name":"School of Medicine and Medical Science University College Dublin Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Evers","sequence":"additional","affiliation":[{"name":"School of Medicine and Medical Science University College Dublin Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Buffini","sequence":"additional","affiliation":[{"name":"School of Medicine and Medical Science University College Dublin Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. M.","family":"Scott","sequence":"additional","affiliation":[{"name":"National Bowel Research Centre (NBRC) and GI Physiology Unit Queen Mary University of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. H.","family":"Knowles","sequence":"additional","affiliation":[{"name":"National Bowel Research Centre (NBRC) and GI Physiology Unit Queen Mary University of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. R.","family":"O'Connell","sequence":"additional","affiliation":[{"name":"School of Medicine and Medical Science University College Dublin Dublin Ireland"},{"name":"Centre for Colorectal Disease St Vincent's University Hospital Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. F. X.","family":"Jones","sequence":"additional","affiliation":[{"name":"School of Medicine and Medical Science University College Dublin Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-6444-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.04.054"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e31821c404a"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-005-1338-x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0002-9378(03)00817-2"},{"issue":"8","key":"e_1_2_8_7_1","first-page":"Cd004464","article-title":"Sacral nerve stimulation for faecal incontinence and constipation in adults","author":"Thaha MA","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9587"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12733"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-008-9283-7"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181ab81fe"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e318236dcab"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.7431"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ilar.43.4.207"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199708000-00015"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)90766-9"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00235.2012"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2010.02208.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-458-2_7"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3084"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.13664","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.13664","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T14:10:23Z","timestamp":1696255823000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.13664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/codi.13664"],"URL":"https:\/\/doi.org\/10.1111\/codi.13664","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"2016-11-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-12-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}