{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:19Z","timestamp":1787014039141,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T00:00:00Z","timestamp":1496361600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Abnormal colonic pressure profiles and high intraluminal pressures are postulated to contribute to the formation of sigmoid colon diverticulosis and the pathophysiology of diverticular disease. This study aimed to review evidence for abnormal colonic pressure profiles in diverticulosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      All published studies investigating colonic pressure in patients with diverticulosis were searched in three databases (Medline, Embase, Scopus). No language restrictions were applied. Any manometry studies in which patients with diverticulosis were compared with controls were included. The Newcastle\u2212Ottawa Quality Assessment Scale (\n                      <jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>\n                      ) for case\u2212control studies was used as a measure of risk of bias. A cut\u2010off of five or more points on the\n                      <jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>\n                      (fair quality in terms of risk of bias) was chosen for inclusion in the meta\u2010analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ten studies (published 1962\u22122005) met the inclusion criteria. The studies followed a wide variety of protocols and all used low\u2010resolution manometry (sensor spacing range 7.5\u221215\u00a0cm). Six studies compared intra\u2010sigmoid pressure, with five of six showing higher pressure in diverticulosis\n                      <jats:italic>vs<\/jats:italic>\n                      controls, but only two reached statistical significance. A meta\u2010analysis was not performed as only two studies were above the cut\u2010off and these did not have comparable outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This systematic review of manometry data shows that evidence for abnormal pressure in the sigmoid colon in patients with diverticulosis is weak. Existing studies utilized inconsistent methodology, showed heterogeneous results and are of limited quality. Higher quality studies using modern manometric techniques and standardized reporting methods are needed to clarify the role of colonic pressure in diverticulosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.13692","type":"journal-article","created":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T03:07:35Z","timestamp":1493003255000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Limited evidence of abnormal intra\u2010colonic pressure profiles in diverticular disease \u2013 a systematic review"],"prefix":"10.1111","volume":"19","author":[{"given":"R.","family":"Jaung","sequence":"first","affiliation":[{"name":"Department of Surgery University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Robertson","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"O'Grady","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Milne","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Rowbotham","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Auckland City Hospital Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. P.","family":"Bissett","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Auckland Auckland New Zealand"},{"name":"Department of Surgery Auckland City Hospital Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15597-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/j.cpsurg.2010.04.005"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X13478679"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000103896"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.194"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4277"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01863.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01308.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(04)00614-7"},{"key":"e_1_2_6_11_1","volume-title":"Validity and Inter\u2010Rater Reliability Testing of Quality Assessment Instruments","author":"Hartling L","year":"2012"},{"key":"e_1_2_6_12_1","volume-title":"Quality Improvement Interventions to Address Health Disparities","author":"McPheeters ML","year":"2012"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)90969-8"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000198481"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365527709180936"},{"key":"e_1_2_6_16_1","first-page":"1398","article-title":"Motility of the signoid in irritable bowel syndrome and colonic diverticulosis [Dutch]. 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