{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:52:48Z","timestamp":1777942368054,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T00:00:00Z","timestamp":1506988800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>During the follow\u2010up of surgically resected colorectal cancer (<jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>), positron emission tomography\u2013contrast\u2010enhanced computed tomography (<jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">CECT<\/jats:styled-content>) is indicated for asymptomatic elevation of carcinoembryonic antigen (<jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content>) &gt;\u00a05\u00a0ng\/ml and no obvious site of recurrence on clinical examination and basic imaging. As an institutional policy, a <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">CECT<\/jats:styled-content> scan was performed at our institute whenever (1) <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content> levels rose above 5\u00a0ng\/ml and (2) <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content> values were doubled (even if the <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content> level was &lt;\u00a05\u00a0ng\/ml). Our aim was to correlate the range of <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content> elevation with recurrence rates and to evaluate the diagnostic utility of <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">CECT<\/jats:styled-content> scanning in this setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We retrospectively analysed all cases where a <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">CECT<\/jats:styled-content> scan was performed for elevated <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content> levels during surveillance visits after complete resection of the primary tumour followed by adjuvant therapy. This study was conducted from 1 January 2013 to 31 July 2015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 104 patients underwent a <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">CECT<\/jats:styled-content> scan for rising <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content> values, and 62 patients (59.6%) were found to have recurrent disease. At <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content> levels &lt;\u00a05, 5.1\u201310, 10.1\u201315, 15.1\u201350 and &gt;\u00a050\u00a0ng\/ml, disease recurred in 10%, 45%, 70%, 94% and 100% patients, respectively. Sensitivity, specificity, positive predictive value and negative predictive value of the <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">CECT<\/jats:styled-content> scan were 92.7%, 95.2%, 96.2% and 90.9%, respectively. Elevation of <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content> levels during follow\u2010up was indicative of recurrence in 68% of the secretors and 45% of the non\u2010secretors (based on baseline <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content> status).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the setting of rising <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content> levels during follow\u2010up of patients with <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>, a <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">CECT<\/jats:styled-content> scan is a valuable tool to detect recurrence, irrespective of the baseline <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content> secretor status. The likelihood of recurrence of disease was directly proportional to the value of the raised <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content> level.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.13695","type":"journal-article","created":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T15:49:16Z","timestamp":1493221756000},"page":"907-911","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Carcinoembryonic antigen directed <scp>PET<\/scp>\u2212<scp>CECT<\/scp> scanning for postoperative surveillance of colorectal cancer"],"prefix":"10.1111","volume":"19","author":[{"given":"K. C.","family":"Vallam","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology Mahatma Gandhi Cancer Hospital and Research Institute Visakhapatnam India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Guruchannabasavaiah","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Caritas Cancer Institute Thellakom Kottayam Kerala India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Tata Memorial Centre Parel Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Rangarajan","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Tata Memorial Centre Parel Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Ostwal","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Tata Memorial Centre Parel Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Engineer","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Tata Memorial Centre Parel Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Saklani","sequence":"additional","affiliation":[{"name":"Department of GI Oncology Tata Memorial Centre Parel Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt354"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu543"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.324.7341.813"},{"key":"e_1_2_6_6_1","unstructured":"National Comprehensive Cancer Network[Internet].https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/colon.pdf(accessed 9 May 2016)."},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2014.0085"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1993.03510080047030"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-013-1659-z"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40644-015-0048-y"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-010-0372-z"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604263"},{"key":"e_1_2_6_13_1","first-page":"CD011134","article-title":"Blood CEA levels for detecting recurrent colorectal cancer","volume":"12","author":"Nicholson BD","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1177\/000313481007601017","article-title":"Surveillance with serial serum carcinoembryonic levels detect colorectal cancer recurrences in patients who are initial nonsecretors","volume":"76","author":"Holt A","year":"2010","journal-title":"Am Surg"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02238010"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.13695","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.13695","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T11:55:58Z","timestamp":1695556558000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.13695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":14,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/codi.13695"],"URL":"https:\/\/doi.org\/10.1111\/codi.13695","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"2016-10-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-02-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-10-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}