{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:28:30Z","timestamp":1790839710512,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Permacol\u2122 collagen paste (Permacol\u2122 paste) is an acellular cross\u2010linked porcine dermal collagen matrix suspension for use in soft\u2010tissue repair. The use of Permacol\u2122 paste in the filling of anorectal fistula tract is a new sphincter\u2010preserving method for fistula repair. The <jats:styled-content style=\"fixed-case\">MASERATI<\/jats:styled-content>100 study was a prospective, observational clinical study with the objective to assess the efficacy of Permacol\u2122 collagen paste for anal fistula repair in 100 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Patients (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>100) with anal fistula were treated, at 10 European surgical sites, with a sphincter\u2010preserving technique using Permacol\u2122 paste. Fistula healing was assessed at 1, 3, 6 and 12\u00a0months post\u2010treatment, with the primary end\u2010point being healing at 6\u00a0months. Faecal continence and patient satisfaction were surveyed at each follow\u2010up; adverse events (<jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>s) were monitored throughout the follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 6\u00a0months postsurgery, 56.7% of patients were healed and the percentage healed was largely maintained, with 53.5% healed at 12\u00a0months. Regarding <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>s, 29.0% of patients had at least one <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>, and 16.0% of patients had one or more procedure\u2010related <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>. Most <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>s reported were minor and similar to those commonly observed after fistula treatment, and the incidence of serious adverse events was low (4.0% of patients). Regardless of treatment outcome, 73.0% of patients were satisfied or very satisfied with the procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Permacol\u2122 paste is a promising sphincter\u2010preserving treatment for anal fistulae and has minimal adverse side\u2010effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.13715","type":"journal-article","created":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T15:29:29Z","timestamp":1494516569000},"page":"243-251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Final results of a European, multicentre, prospective, observational study of Permacol\u2122 collagen paste injection for the treatment of anal fistula"],"prefix":"10.1111","volume":"20","author":[{"given":"P.","family":"Giordano","sequence":"first","affiliation":[{"name":"Colorectal Department Whipps Cross University Hospital Barts Health London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Sileri","sequence":"additional","affiliation":[{"name":"Surgery University of Rome Tor Vergata Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Buntzen","sequence":"additional","affiliation":[{"name":"Colorectal Surgery Department of Surgery Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Nunoo\u2010Mensah","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Lenisa","sequence":"additional","affiliation":[{"name":"General Surgery Unit Casa di Cura Humanitas San Pio X Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Singh","sequence":"additional","affiliation":[{"name":"Leicester General Hospital Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Thorlacius\u2010Ussing","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Griffiths","sequence":"additional","affiliation":[{"name":"NUTH Foundation Trust Newcastle UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Vujovic","sequence":"additional","affiliation":[{"name":"Ninewells Hospital &amp; 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