{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T06:02:41Z","timestamp":1759730561371},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Little is known about the epidemiology of sessile serrated polyps (SSP). Our study aimed to investigate the influence of <jats:italic>Helicobacter pylori<\/jats:italic> gastritis and patient demographic characteristics (age, gender, ethnicity) on the prevalence of SSP using a large national database of patients undergoing bi\u2010directional endoscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>De\u2010identified patient data were extracted from the Miraca Life Sciences electronic database of histopathological reports. Using multivariate logistic regression analysis, the influence of <jats:italic>H.\u00a0pylori<\/jats:italic> gastritis and demographic characteristics on the occurrence of SSP were expressed as odds ratios (OR) with their 95% confidence intervals (CI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The total study population comprised 228\u00a0506 subjects, of whom 28\u00a0890 carried a diagnosis of <jats:italic>H.\u00a0pylori<\/jats:italic> gastritis and 11\u00a0285 SSP. Age (OR 4.35, 95% CI: 3.82\u20134.96), female gender (0.92, 0.88\u20130.95) and <jats:italic>H.\u00a0pylori<\/jats:italic> gastritis (0.94, 0.88\u20130.99) exerted the strongest influence on the occurrence of SSP. In comparison with the population comprising Caucasians and African Americans, SSP were less common among subjects of\u00a0Hispanic (0.67, 0.62\u20130.73), East Asian (0.59, 0.50\u20130.69), Indian (0.43, 0.27\u20130.64) or Middle Eastern descent (0.61, 0.41\u20130.87). All these ethnic subgroups were also characterized by a higher prevalence of <jats:italic>H.\u00a0pylori<\/jats:italic> than the comparison group. A low prevalence of <jats:italic>H.\u00a0pylori<\/jats:italic> was significantly associated with a high prevalence of SSP (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.82, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of SSP within the United States is characterized by a marked ethnic variation. The inverse correlation between the prevalence of <jats:italic>H.\u00a0pylori<\/jats:italic> and SSP suggests that gastric infection with <jats:italic>H.\u00a0pylori<\/jats:italic> may be partly responsible for the observed ethnic distribution of SSP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.13716","type":"journal-article","created":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T21:12:46Z","timestamp":1494537166000},"page":"996-1002","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The ethnic distribution of sessile serrated polyps in the United States is inversely associated with <i>Helicobacter pylori<\/i> prevalence"],"prefix":"10.1111","volume":"19","author":[{"given":"A.","family":"Sonnenberg","sequence":"first","affiliation":[{"name":"Miraca Life Sciences Irving Texas USA"},{"name":"Oregon Health and Science University Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. 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