{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:23:17Z","timestamp":1762917797538,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004886","name":"Cancer Research Foundation in Northern Sweden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004886","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Previous research indicates that high tie of the inferior mesenteric artery during anterior resection for rectal cancer might be associated with an increased risk of postoperative functional disturbances. The goal of this population\u2010based retrospective cohort study was to further investigate that association.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Patients who underwent anterior resection for rectal cancer from April 2011 to September 2012 were identified through the Swedish Colorectal Cancer Registry. Bowel and urogenital function were assessed by a postal questionnaire 2\u00a0years after surgery. Information on the level of mesenteric tie and clinical variables was retrieved from the registry. The outcome was defined as any defaecatory, urinary or sexual dysfunction as reported by the patient. The association between high tie and the outcome was evaluated with multivariable logistic and linear regression with adjustment for confounders, such as sex, body mass index, comorbidity and preoperative radiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>With a response rate of 86%, 805 patients were included in the study. Of these, 46% were operated with high tie. After adjustment for confounders, high tie did not affect the risk of faecal incontinence (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.85; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.59\u20131.22), urinary incontinence (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.94; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.63\u20131.41) or various aspects of sexual dysfunction (erectile dysfunction, anejaculation, dyspareunia and coital vaginal dryness). However, an association between high tie and defaecation at night was detected (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.44; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.02\u20132.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study does not support that the level of vascular tie influences the risk of major defaecatory, urinary or sexual disturbances 2\u00a0years after anterior resection for rectal cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.13745","type":"journal-article","created":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T17:24:01Z","timestamp":1495733041000},"page":"987-995","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Level of vascular tie and its effect on functional outcome 2\u00a0years after anterior resection for rectal cancer"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4958-6965","authenticated-orcid":false,"given":"D.","family":"Kverneng Hultberg","sequence":"first","affiliation":[{"name":"Department of Surgical and Perioperative Sciences Surgery Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. A.","family":"Afshar","sequence":"additional","affiliation":[{"name":"Department of Surgical and Perioperative Sciences Surgery Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Ruteg\u00e5rd","sequence":"additional","affiliation":[{"name":"Department of Surgical and Perioperative Sciences Surgery Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lange","sequence":"additional","affiliation":[{"name":"Department of Surgery Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. M.","family":"Haapam\u00e4ki","sequence":"additional","affiliation":[{"name":"Department of Surgical and Perioperative Sciences Surgery Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Matthiessen","sequence":"additional","affiliation":[{"name":"Department of Surgery Faculty of Medicine and Health School of Health and Medical Sciences \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ruteg\u00e5rd","sequence":"additional","affiliation":[{"name":"Department of Surgical and Perioperative Sciences Surgery Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Rektalcancer: Nationell kvalitetsrapport f\u00f6r \u00e5r 2014 fr\u00e5n Svenska Kolorektalcancerregistret.[Rectal cancer: National report for the year 2014 from the Swedish Colorectal Cancer Registry.]Ume\u00e5 Sweden:Northern regional cancer centre;2015.http:\/\/www.cancercentrum.se\/globalassets\/cancerdiagnoser\/tjock--och-andtarm-anal\/kvalitetsregister\/nationell-kvalitetsregisterrapport-andtarmscancer-2014.pdf(accessed March 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