{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:02:26Z","timestamp":1787317346425,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T00:00:00Z","timestamp":1514937600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      The construction of a new coloanal anastomosis (\n                      <jats:styled-content style=\"fixed-case\">CAA<\/jats:styled-content>\n                      ) following anastomotic leakage after low anterior resection (\n                      <jats:styled-content style=\"fixed-case\">LAR<\/jats:styled-content>\n                      ) is challenging. The available literature on this topic is scarce. The aim of this two\u2010centre study was to determine the clinical success and morbidity after redo\n                      <jats:styled-content style=\"fixed-case\">CAA<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      This retrospective cohort study included all patients with anastomotic leakage after\n                      <jats:styled-content style=\"fixed-case\">LAR<\/jats:styled-content>\n                      for rectal cancer who underwent a redo\n                      <jats:styled-content style=\"fixed-case\">CAA<\/jats:styled-content>\n                      between 2010 and 2014 in two tertiary referral centres. Short\u2010 and long\u2010term morbidity were analysed, including both anastomotic leakage and permanent stoma rates on completion of follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 59 patients were included, of whom 45 (76%) were men, with a mean age of 59\u00a0years (\n                      <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n                      \u00a0\n                      <jats:italic>\u00b1<\/jats:italic>\n                      \u00a09.4). The median interval between index and redo surgery was 14\u00a0months [interquartile range (\n                      <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\n                      ) 8\u201327]. The median duration of follow\u2010up was 27\u00a0months (\n                      <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\n                      17\u201336). The most frequent complication was anastomotic leakage of the redo\n                      <jats:styled-content style=\"fixed-case\">CAA<\/jats:styled-content>\n                      occurring in 24 patients (41%), resulting in a median of three reinterventions (\n                      <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\n                      2\u20134) per patient. At the end of follow\u2010up, bowel continuity was restored in 39\/59 (66%) patients. Fourteen (24%) patients received a definitive colostomy and six (10%) still had a diverting ileostomy. In a multivariable model, leakage of the redo\n                      <jats:styled-content style=\"fixed-case\">CAA<\/jats:styled-content>\n                      was the only risk factor for permanent stoma (\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      0.022; 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      0.004\u20130.122).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Redo\n                      <jats:styled-content style=\"fixed-case\">CAA<\/jats:styled-content>\n                      is a viable option in selected patients with persisting leakage after\n                      <jats:styled-content style=\"fixed-case\">LAR<\/jats:styled-content>\n                      for rectal cancer who want their bowel continuity restored. However, patients should be fully informed about the relatively high morbidity and reintervention rates.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.13844","type":"journal-article","created":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T05:17:11Z","timestamp":1502342231000},"page":"35-43","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Redo coloanal anastomosis for anastomotic leakage after low anterior resection for rectal cancer: an analysis of 59 cases"],"prefix":"10.1111","volume":"20","author":[{"given":"E.","family":"Westerduin","sequence":"first","affiliation":[{"name":"Department of Surgery Academic Medical Centre University of Amsterdam Amsterdam the Netherlands"},{"name":"Department of Surgery Tergooi Hospital Hilversum the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. A. A.","family":"Borstlap","sequence":"additional","affiliation":[{"name":"Department of Surgery Academic Medical Centre University of Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. D.","family":"Musters","sequence":"additional","affiliation":[{"name":"Department of Surgery Academic Medical Centre University of Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Westerterp","sequence":"additional","affiliation":[{"name":"Department of Abdominal Surgery University Hospital Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. A. W.","family":"van Geloven","sequence":"additional","affiliation":[{"name":"Department of Surgery Tergooi Hospital Hilversum the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. J.","family":"Tanis","sequence":"additional","affiliation":[{"name":"Department of Surgery Academic Medical Centre University of Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"Wolthuis","sequence":"additional","affiliation":[{"name":"Department of Abdominal Surgery University Hospital Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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