{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:18Z","timestamp":1787014038236,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,6,3]],"date-time":"2018-06-03T00:00:00Z","timestamp":1527984000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      Postoperative ileus (\n                      <jats:styled-content style=\"fixed-case\">POI<\/jats:styled-content>\n                      ) is characterised by delayed gastrointestinal recovery and is common after colorectal surgery. Numerous strategies to optimise\n                      <jats:styled-content style=\"fixed-case\">POI<\/jats:styled-content>\n                      have been proposed but its management remains an unmet clinical need. This study aimed to characterise the duration and management of gastrointestinal recovery in patients undergoing elective colorectal surgery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      A snapshot, prospective, observational study was undertaken between November 2016 and January 2017 at 10 regional hospitals in the United Kingdom. Adult patients undergoing elective colorectal surgery with resection of bowel or reversal of stoma were included. Outcomes included time until return of gastrointestinal function, timing of nasogastric tube (\n                      <jats:styled-content style=\"fixed-case\">NGT<\/jats:styled-content>\n                      ) insertion, uptake of targeted interventions and clinical outcomes. Data were validated for accuracy by independent investigators.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      204 patients met the eligibility criteria. The median time for gastrointestinal recovery was 3\u00a0days (\n                      <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\n                      2\u20134); right\u2010sided resections were associated with longer gastrointestinal recovery than left sided (4\u00a0days (2.75\u20135.25)\n                      <jats:italic>vs<\/jats:italic>\n                      3\u00a0days (2\u20134);\n                      <jats:italic>P\u00a0=\u00a0<\/jats:italic>\n                      0.002). The rate of\n                      <jats:styled-content style=\"fixed-case\">NGT<\/jats:styled-content>\n                      insertion was 22.5% at a median time of 4 (4\u20134.75)\u00a0days.\n                      <jats:styled-content style=\"fixed-case\">NGT<\/jats:styled-content>\n                      insertion after vomiting was associated with a higher incidence of bronchopneumonia compared to early placement (13.3%\n                      <jats:italic>vs<\/jats:italic>\n                      29.0%). Targeted interventions, such as chewing gum (4.4%), selective mu\u2010receptor antagonists (1.0%) and pro\u2010kinetic agents (13.7%) were infrequently used.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The average time to gastrointestinal recovery after elective colorectal surgery was three days. Late\n                      <jats:styled-content style=\"fixed-case\">NGT<\/jats:styled-content>\n                      insertion was associated with an increased incidence of bronchopneumonia. The clinical uptake of targeted interventions to improve gastrointestinal recovery was poor.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.13949","type":"journal-article","created":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T10:16:34Z","timestamp":1509531394000},"page":"536-544","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Multicentre observational study of gastrointestinal recovery after elective colorectal surgery"],"prefix":"10.1111","volume":"20","author":[{"name":"Yorkshire Surgical Research Collaborative","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,3]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"e164681","article-title":"Associations of specific postoperative complications with outcomes after elective colon resection: a procedure\u2010targeted approach toward surgical quality improvement","volume":"7","author":"Scarborough JE","year":"2016","journal-title":"JAMA Surg"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2009.15.6.485"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-012-1772-0"},{"issue":"2","key":"e_1_2_9_5_1","first-page":"CD006506","article-title":"Chewing gum for postoperative recovery of gastrointestinal function","author":"Short V","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"e_1_2_9_6_1","first-page":"CD004080","article-title":"Early enteral nutrition within 24\u00a0h of colorectal surgery versus later commencement of feeding for postoperative complications","author":"Andersen HK","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.12790"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39335.541782.AD"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62013-9"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2015.04.079"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.10.1043"},{"key":"e_1_2_9_12_1","unstructured":"Scottish Intercollegiate Guidelines Network (SIGN).Control of pain in adults with cancer.http:\/\/www.sign.ac.uk\/assets\/sign106.pdf(accessed 11 July 2017)."},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.13582"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-016-3140-0"},{"issue":"7","key":"e_1_2_9_15_1","first-page":"CD009642","article-title":"Continuous intravenous perioperative lidocaine infusion for postoperative pain and recovery","author":"Kranke P","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-011-1655-y"},{"key":"e_1_2_9_17_1","article-title":"Prospective comparison of return of bowel function after left versus right colectomy","author":"Yuan L","year":"2016","journal-title":"ANZ J Surg"},{"key":"e_1_2_9_18_1","first-page":"890","article-title":"Periodic rectal motor activity: the intrinsic colonic gatekeeper?","volume":"91","author":"Rao SS","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20965"},{"issue":"7","key":"e_1_2_9_20_1","first-page":"CD001893","article-title":"Epidural local anaesthetics versus opioid\u2010based analgesic regimens for postoperative gastrointestinal paralysis, vomiting and pain after abdominal surgery","author":"Guay J","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199804000-00029"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-015-0918-4"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.13210"},{"key":"e_1_2_9_24_1","unstructured":"DelaneyCP KehletH SenagoreAet\u00a0al.Clinical Consensus Update in General Surgery postoperative ileus: profiles risk factors and definitions \u2013 a framework for optimizing surgical outcomes in patients undergoing major abdominal and colorectal surgery. Clinical Consensus Update in General Surgery [Consensus statement].2006.http:\/\/www.clinicalwebcasts.com\/pdfs\/GenSurg_WEB.pdf(accessed 10 April 2017)."},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(17)30033-X"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-017-2789-5"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.13949","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.13949","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T09:18:59Z","timestamp":1695460739000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.13949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/codi.13949"],"URL":"https:\/\/doi.org\/10.1111\/codi.13949","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"2017-05-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-10-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}