{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T18:30:18Z","timestamp":1781202618495,"version":"3.54.1"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,6,3]],"date-time":"2018-06-03T00:00:00Z","timestamp":1527984000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006356","name":"Syddansk Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006356","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004196","name":"Odense Universitetshospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008363","name":"Kr\u00e6ftens Bek\u00e6mpelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim was to determine the polyp detection rate and per\u2010patient sensitivity for polyps &gt;\u00a09\u00a0mm of colon capsule endoscopy (<jats:styled-content style=\"fixed-case\">CCE<\/jats:styled-content>) compared with colonoscopy as well as the diagnostic accuracy of <jats:styled-content style=\"fixed-case\">CCE<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Individuals who had a positive immunochemical faecal occult blood test during screening had investigator blinded <jats:styled-content style=\"fixed-case\">CCE<\/jats:styled-content> and colonoscopy. Participants underwent repeat endoscopy if significant lesions detected by <jats:styled-content style=\"fixed-case\">CCE<\/jats:styled-content> were considered to have been missed by colonoscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 253 participants. The polyp detection rate was significantly higher in <jats:styled-content style=\"fixed-case\">CCE<\/jats:styled-content> compared with colonoscopy (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.02). The per\u2010patient sensitivity for &gt;\u00a09\u00a0mm polyps for <jats:styled-content style=\"fixed-case\">CCE<\/jats:styled-content> and colonoscopy was 87% (95% CI: 83\u201391%) and 88% (95% CI: 84\u201392%) respectively. In participants with complete <jats:styled-content style=\"fixed-case\">CCE<\/jats:styled-content> and colonoscopy examinations (<jats:italic>N\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>126), per\u2010patient sensitivity of &gt;\u00a09\u00a0mm polyps in <jats:styled-content style=\"fixed-case\">CCE<\/jats:styled-content> (97%; 95% CI: 94\u2013100%) was superior to colonoscopy (89%; 95% CI: 84\u201394%). A complete capsule endoscopy examination (<jats:italic>N\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>134) could detect patients with intermediate or greater risk (according to the European guidelines) with an accuracy, sensitivity, specificity and positivity rate of 79%, 93%, 69% and 58% respectively, using a cut\u2010off of at least one polyp &gt;\u00a010\u00a0mm or more than two polyps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CCE<\/jats:styled-content> is superior to colonoscopy in polyp detection rate and per\u2010patient sensitivity to &gt;\u00a09\u00a0mm polyps, but only in complete <jats:styled-content style=\"fixed-case\">CCE<\/jats:styled-content> examinations. The rate of incomplete <jats:styled-content style=\"fixed-case\">CCE<\/jats:styled-content> examinations must be improved.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.13965","type":"journal-article","created":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T17:52:42Z","timestamp":1511373162000},"page":"479-485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Back\u2010to\u2010back colon capsule endoscopy and optical colonoscopy in colorectal cancer screening individuals"],"prefix":"10.1111","volume":"20","author":[{"given":"M.","family":"Kobaek\u2010Larsen","sequence":"first","affiliation":[{"name":"Department of Surgery Odense University Hospital Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Kroijer","sequence":"additional","affiliation":[{"name":"Department of Surgery Odense University Hospital Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.\u2010K.","family":"Dyrvig","sequence":"additional","affiliation":[{"name":"Department of Surgery Odense University Hospital Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark Odense Denmark"},{"name":"OPEN, Odense Patient Data Explorative Network Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. M.","family":"Buijs","sequence":"additional","affiliation":[{"name":"Department of Surgery Odense University Hospital Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J. C.","family":"Steele","sequence":"additional","affiliation":[{"name":"Dundee University Hospital and National Screening Centre Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Qvist","sequence":"additional","affiliation":[{"name":"Department of Surgery Odense University Hospital Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Baatrup","sequence":"additional","affiliation":[{"name":"Department of Surgery Odense University Hospital Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2980.2010.00430.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-995618"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1365402"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.04.038"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.12.027"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1344548"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0907667"},{"key":"e_1_2_7_9_1","unstructured":"Annual Report2015 Danish Colorectal Cancer Screening Database.https:\/\/www.sundhed.dk\/content\/cms\/45\/61245_dtsarsrapport-2015_final.pdf(accessed December 2016)."},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.01.025"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-306550"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1393075"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01404.x"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.13965","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.13965","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T13:18:39Z","timestamp":1695475119000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.13965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/codi.13965"],"URL":"https:\/\/doi.org\/10.1111\/codi.13965","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"2017-07-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}