{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T05:47:27Z","timestamp":1785476847580,"version":"3.56.0"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,8,2]],"date-time":"2018-08-02T00:00:00Z","timestamp":1533168000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Ovarian metastases from gastrointestinal tract malignancies have been considered an ominous finding with poor prognosis. The aim of this project was to determine the impact on survival, and potential cure, when cytoreductive surgery (<jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>) and hyperthermic intraperitoneal chemotherapy (<jats:styled-content style=\"fixed-case\">HIPEC<\/jats:styled-content>) are combined to treat peritoneal malignancy in women with Krukenberg tumours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A retrospective analysis of prospectively collected data between January 2010 and July 2015. Female patients undergoing complete <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content> (macroscopic tumour removal) and <jats:styled-content style=\"fixed-case\">HIPEC<\/jats:styled-content> for pseudomyxoma peritonei (<jats:styled-content style=\"fixed-case\">PMP<\/jats:styled-content>) of appendiceal origin, or colorectal peritoneal metastases (<jats:styled-content style=\"fixed-case\">CPM<\/jats:styled-content>) were included. Survival was estimated using the Kaplan\u2013Meier method and survival rates compared using the log\u2010rank test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 889 patients underwent surgery for peritoneal malignancy, of whom 551 were female. Of these, 504\/551 (91%) underwent complete <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HIPEC<\/jats:styled-content>. Overall, 405\/504 (80%) had at least one involved ovary removed either during <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HIPEC<\/jats:styled-content> or at their index prereferral operation. Three hundred and fifty\u2010two patients (87%) had an appendiceal tumour and 53 (13%) had <jats:styled-content style=\"fixed-case\">CPM<\/jats:styled-content>. At a median follow up of 40\u00a0months, overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) did not differ significantly between patients with or without ovarian involvement in women with a primary low\u2010grade appendiceal tumour or <jats:styled-content style=\"fixed-case\">CPM<\/jats:styled-content>. In women with high\u2010grade primary appendiceal pathology, <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> was significantly lower in patients with ovarian metastases compared with those without ovarian involvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Women with ovarian metastases from low\u2010grade appendiceal tumours or colorectal cancer treated with <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HIPEC<\/jats:styled-content> have similar survival rates to patients without ovarian metastases. Long\u2010term survival and cure is feasible in patients amenable to complete tumour removal.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.14057","type":"journal-article","created":{"date-parts":[[2018,3,4]],"date-time":"2018-03-04T12:46:36Z","timestamp":1520167596000},"page":"704-710","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Impact of ovarian metastases on survival in patients treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal malignancy originating from appendiceal and colorectal cancer"],"prefix":"10.1111","volume":"20","author":[{"given":"M. B.","family":"Bignell","sequence":"first","affiliation":[{"name":"Peritoneal Malignancy Institute Basingstoke amd North Hampshire Hospital Hampshire Hospitals NHS Foundation Trust Basingstoke UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4973-3016","authenticated-orcid":false,"given":"A. M.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Peritoneal Malignancy Institute Basingstoke amd North Hampshire Hospital Hampshire Hospitals NHS Foundation Trust Basingstoke UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Alves","sequence":"additional","affiliation":[{"name":"Peritoneal Malignancy Institute Basingstoke amd North Hampshire Hospital Hampshire Hospitals NHS Foundation Trust Basingstoke UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Chandrakumaran","sequence":"additional","affiliation":[{"name":"Peritoneal Malignancy Institute Basingstoke amd North Hampshire Hospital Hampshire Hospitals NHS Foundation Trust Basingstoke UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. P.","family":"Dayal","sequence":"additional","affiliation":[{"name":"Peritoneal Malignancy Institute Basingstoke amd North Hampshire Hospital Hampshire Hospitals NHS Foundation Trust Basingstoke UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Peritoneal Malignancy Institute Basingstoke amd North Hampshire Hospital Hampshire Hospitals NHS Foundation Trust Basingstoke UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. D.","family":"Cecil","sequence":"additional","affiliation":[{"name":"Peritoneal Malignancy Institute Basingstoke amd North Hampshire Hospital Hampshire Hospitals NHS Foundation Trust Basingstoke UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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