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At present the known molecular markers are limited in their frequency and reliability in determining the use of newer chemotherapies. Professor Eng discusses the challenges faced in ensuring timely and effective treatments based on the molecular profile of the tumour and the potential role of real\u2010time analysis of mutational changes in the tumour when progression occurs.<\/jats:p>","DOI":"10.1111\/codi.14079","type":"journal-article","created":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T23:33:21Z","timestamp":1527809601000},"page":"49-51","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Session 2: Mutational discordance: the big challenge in personalized treatments \u2013 any solutions?"],"prefix":"10.1111","volume":"20","author":[{"given":"M.","family":"Siddiqui","sequence":"first","affiliation":[{"name":"The Royal Marsden NHS Foundation Trust Croydon University Hospital Croydon UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Chand","sequence":"additional","affiliation":[{"name":"University College London Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Eng","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal (GI) Medical Oncology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Mehdizadeh","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal (GI) Medical Oncology Division of Cancer Medicine The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Mirnezami","sequence":"additional","affiliation":[{"name":"University of Southampton Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Brown","sequence":"additional","affiliation":[{"name":"The Royal Marsden NHS Foundation Trust London UK"},{"name":"Imperial College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00122-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11156"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2014.895036"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu141"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70330-4"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1113205"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2015.12.005"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-15-1483"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.14079","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.14079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T16:49:43Z","timestamp":1694450983000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.14079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":8,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/codi.14079"],"URL":"https:\/\/doi.org\/10.1111\/codi.14079","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"2018-05-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}