{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:39:18Z","timestamp":1790386758115,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,5,13]],"date-time":"2018-05-13T00:00:00Z","timestamp":1526169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to analyse the potential significance of metastasis to the inferior mesenteric artery lymph node (IMA\u2010LN) in patients with malignancy of the left colon and rectum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A retrospective analysis of a cohort of 890 patients collected prospectively who underwent radical resection of a primary tumour of the descending colon, sigmoid colon and rectum in our department from 1 January 2009 to 31 December 2015 was performed. Patients were divided into an IMA\u2010LN metastasis (<jats:styled-content style=\"fixed-case\">IMA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content> (+)) group (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>51) and a non IMA\u2010LN metastasis (IMA\u2010LN (\u2010)) group (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>839). A total of 801 patients were followed by a designated member of the study staff. Clinical features, pathological characteristics, recurrence patterns and survival rates were compared between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the <jats:styled-content style=\"fixed-case\">IMA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content> (+) group, the risk ratio of overall recurrence and tumour related death was 7.786 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 4.142\u201314.637) and 7.756 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 4.142\u201314.525) respectively. Significant differences were found in overall survival (log\u2010rank: \u03c7<jats:sup>2<\/jats:sup>\u00a0=\u00a069.06, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001) and disease\u2010free survival (log\u2010rank: \u03c7<jats:sup>2<\/jats:sup>\u00a0=\u00a069.06, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001) between the two groups. Furthermore, there were significant differences in overall survival (log\u2010rank: \u03c7<jats:sup>2<\/jats:sup>\u00a0=\u00a018.47, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001) and disease\u2010free survival (log\u2010rank: \u03c7<jats:sup>2<\/jats:sup>\u00a0=\u00a016.99, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001) between the <jats:styled-content style=\"fixed-case\">IMA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content> (\u2212) and <jats:styled-content style=\"fixed-case\">IMA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content> (+) subgroups of patients with Stage N2 disease. Multivariate survival analysis indicated that <jats:styled-content style=\"fixed-case\">IMA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content> (+) was an independent risk factor of poor prognosis. There was no difference in the prognosis between high tie and low tie with <jats:styled-content style=\"fixed-case\">IMA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content> dissection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Inferior mesenteric artery lymph node metastasis was an independent predictive factor for high systemic recurrence. Low ligation of the <jats:styled-content style=\"fixed-case\">IMA<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">IMA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content> dissection was not inferior to high ligation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.14105","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T01:53:31Z","timestamp":1522029211000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Prognostic value of inferior mesenteric artery lymph node metastasis in cancer of the descending colon, sigmoid colon and rectum"],"prefix":"10.1111","volume":"20","author":[{"given":"X.","family":"Rao","sequence":"first","affiliation":[{"name":"Department of General Surgery Peking University First Hospital Beijing PR 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