{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:48:32Z","timestamp":1787240912107,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T00:00:00Z","timestamp":1532044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2018,12]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n \n To determine the pathological features of colonic ischaemia (\n CI<\/jats:styled-content>\n ) and their relationship to symptom duration, disease distribution and clinical outcome in a real\u2010world, clinical setting.\n <\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n \n A retrospective, multicentre chart review was performed in patients diagnosed with\n CI<\/jats:styled-content>\n at Montefiore Medical Center (January 2005 to July 2015), and Yale\u2010New Haven Hospital (January 2005 to June 2010). Patients were included if clinical presentation, colonoscopic findings and colonic pathology were all consistent with\n CI<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Six hundred and sixteen patients with pathologically proven\n CI<\/jats:styled-content>\n were included. Common pathological findings included inflammation (51.1%), ulceration (38.2%), fibrosis (26.0%) and necrosis (20.4%). Infarction and ghost cells were seen in 1.6% and 0.2% of cases, respectively. There was a significant relationship between symptom duration and hyalinization of the lamina propria (\n P<\/jats:italic>\n = 0.05) and cryptitis\/crypt abscesses (\n P<\/jats:italic>\n = 0.01). Patients with isolated right\n CI<\/jats:styled-content>\n (\n IRCI<\/jats:styled-content>\n ) were more likely than patients with isolated left\n CI<\/jats:styled-content>\n (\n ILCI<\/jats:styled-content>\n ) to exhibit necrosis (\n P<\/jats:italic>\n < 0.01), cryptitis\/crypt abscess (\n P<\/jats:italic>\n < 0.01) and inflammation (\n P<\/jats:italic>\n = 0.03). Patients with poor outcomes were more likely to exhibit necrosis (\n P<\/jats:italic>\n < 0.01) and capillary fibrin thrombi (\n P<\/jats:italic>\n < 0.01) and less likely to exhibit fibrosis (\n P<\/jats:italic>\n < 0.01) and epithelial changes (\n P<\/jats:italic>\n < 0.01).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n CI<\/jats:styled-content>\n is accompanied by a broad spectrum of pathological findings. The traditional pathognomonic findings of\n CI<\/jats:styled-content>\n are rare and cannot be relied upon to exclude the diagnosis. Patients with\n IRCI<\/jats:styled-content>\n and\/or poor outcomes were more likely to have pathological findings of necrosis than patients who had\n ILCI<\/jats:styled-content>\n and\/or nonpoor outcomes.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/codi.14323","type":"journal-article","created":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T10:23:59Z","timestamp":1530613439000},"page":"1132-1141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Real\u2010world multicentre experience of the pathological features of colonic ischaemia and their relationship to symptom duration, disease distribution and clinical outcome"],"prefix":"10.1111","volume":"20","author":[{"given":"M.","family":"Fenster","sequence":"first","affiliation":[{"name":"Albert Einstein College of Medicine Montefiore Medical Center Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Feuerstadt","sequence":"additional","affiliation":[{"name":"Yale University School of Medicine New Haven Connecticut USA"},{"name":"Gastroenterology Center of Connecticut Hamden Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. J.","family":"Brandt","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine Montefiore Medical Center Bronx New York USA"},{"name":"Division of Gastroenterology Albert Einstein College of Medicine Montefiore Medical Center Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. S.","family":"Mansoor","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yale\u2010New Haven Hospital New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Huisman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. C.","family":"Aroniadis","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine Montefiore Medical Center Bronx New York USA"},{"name":"Division of Gastroenterology Albert Einstein College of Medicine Montefiore Medical Center Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,20]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"2076","volume-title":"Sleisenger & Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management","author":"Brandt LJ","year":"2015"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e32835948e3"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e328344ccb5"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.05.026"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.07.061"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03250.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.395"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-011-1205-5"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(16)45627-6"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0579-1"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199706000-00011"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2010.525794"},{"key":"e_1_2_10_14_1","first-page":"239","article-title":"Colitis in the elderly. A reappraisal","volume":"76","author":"Brandt L","year":"1981","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.217"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.01903.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01341.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.04.011"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3393\/jksc.2011.27.6.282"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.14323","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.14323","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T11:52:10Z","timestamp":1694778730000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.14323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,20]]},"references-count":18,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1111\/codi.14323"],"URL":"https:\/\/doi.org\/10.1111\/codi.14323","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,20]]},"assertion":[{"value":"2018-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}