{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:48:22Z","timestamp":1791593302025,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T00:00:00Z","timestamp":1542758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Published outcomes following ligation of the intersphincteric fistula tract (<jats:styled-content style=\"fixed-case\">LIFT<\/jats:styled-content>) for high transsphincteric fistulas (<jats:styled-content style=\"fixed-case\">HTF<\/jats:styled-content>s) are equivocal probably because most trials are small and comprise mixed patient populations. The aim of this study was to highlight the long\u2010term efficacy of <jats:styled-content style=\"fixed-case\">LIFT<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">HTF<\/jats:styled-content>s in a large homogeneous sample and to determine the risk factors that contribute to non\u2010healing resulting in failure and recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A retrospective study was performed which assessed patients with <jats:styled-content style=\"fixed-case\">HTF<\/jats:styled-content>s treated by <jats:styled-content style=\"fixed-case\">LIFT<\/jats:styled-content> without prior loose setons from September 2012 to December 2017. Continence function was evaluated by the Wexner incontinence scale and anal manometry. Quality of life was assessed by using the faecal incontinence quality of life (<jats:styled-content style=\"fixed-case\">FIQL<\/jats:styled-content>) scale with four domains: lifestyle, coping, depression and embarrassment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy patients with <jats:styled-content style=\"fixed-case\">HTF<\/jats:styled-content>s underwent 71 <jats:styled-content style=\"fixed-case\">LIFT<\/jats:styled-content> procedures. The primary healing rate was 81.7% with a median follow\u2010up duration of 16.5 (range 4.5\u201368) months. The healing rates of mature and immature fistulas were 83.7% and 77.3%, respectively. Two patients suffered failure with an unhealed intersphincteric wound. Recurrence occurred in 11 patients. Incontinence of flatus, present in four patients before surgery, improved postoperatively. Two patients undergoing <jats:styled-content style=\"fixed-case\">LIFT<\/jats:styled-content> combined with fistulotomy complained of flatus incontinence after surgery. No significant differences between preoperative and postoperative Wexner score, maximum resting pressure and maximum squeeze pressure were detected. The <jats:styled-content style=\"fixed-case\">FIQL<\/jats:styled-content> was improved in lifestyle, coping and depression. No risk factor for non\u2010healing was found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">LIFT<\/jats:styled-content> has a promising long\u2010term outcome for <jats:styled-content style=\"fixed-case\">HTF<\/jats:styled-content>s, with negligible impairment on continence and improved quality of life.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.14405","type":"journal-article","created":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T15:25:58Z","timestamp":1536161158000},"page":"30-37","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Long\u2010term outcomes and quality of life following ligation of the intersphincteric fistula tract for high transsphincteric fistulas"],"prefix":"10.1111","volume":"21","author":[{"given":"X.\u2010L.","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery Suzhou Affiliated 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.\u2010P.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Suzhou Affiliated Hospital of Nanjing University of Chinese Medicine Suzhou 215000 Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181c160c4"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000374"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e318206043e"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-011-1350-1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-016-1450-6"},{"key":"e_1_2_10_7_1","first-page":"85","article-title":"A systematic review and meta\u2010analysis of the efficacy and safety of 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