{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:19:58Z","timestamp":1767651598336,"version":"3.37.3"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T00:00:00Z","timestamp":1538956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Restorative proctocolectomy has gained acceptance in the surgical management of medically refractive ulcerative colitis and cancer prevention in familial adenomatous polyposis. Incontinence following restorative proctocolectomy occurs in up to 25% of patients overnight. The Renew<jats:sup>\u00ae<\/jats:sup> insert is an inert single\u2010use device which acts as an anal plug. The aim of this study was to assess the acceptability, effectiveness and safety of the Renew<jats:sup>\u00ae<\/jats:sup> insert in patients who have undergone restorative proctocolectomy. The device has yet to be assessed in patients who have undergone restorative proctocolectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This was a prospective study exploring the acceptability, effectiveness and safety of the Renew<jats:sup>\u00ae<\/jats:sup> insert in improving incontinence in patients who had undergone restorative proctocolectomy. A total of 15 patients with incontinence were asked to use the Renew<jats:sup>\u00ae<\/jats:sup> insert for 14\u00a0days following their standard care. The Incontinence Questionnaire\u2013Bowels was used pre\u2010 and posttreatment to assess response and patients were asked to report the perceived acceptability, effectiveness and safety of the device at the end of the trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The device was acceptable to 8\/15 (53%) of patients and was effective in 6\/15 (40%). Only 2\/15 (13%) of patients raised any safety concerns, and these were minor. The device was associated with a significant reduction in night seepage (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.034).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In a small study, the Renew<jats:sup>\u00ae<\/jats:sup> insert can be both acceptable and effective and is also associated with few safety concerns. It is also associated with significant reductions in night\u2010time seepage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.14422","type":"journal-article","created":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T13:16:59Z","timestamp":1537103819000},"page":"73-78","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Acceptability, effectiveness and safety of a Renew<sup>\u00ae<\/sup> anal insert in patients who have undergone restorative proctocolectomy with ileal pouch\u2013anal anastomosis"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9668-0316","authenticated-orcid":false,"given":"J. P.","family":"Segal","sequence":"first","affiliation":[{"name":"St Mark's Hospital Harrow UK"},{"name":"Department of Surgery and Cancer Imperial College London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. A.","family":"Leo","sequence":"additional","affiliation":[{"name":"St Mark's Hospital Harrow UK"},{"name":"Department of Surgery and Cancer Imperial College London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. D.","family":"Hodgkinson","sequence":"additional","affiliation":[{"name":"St Mark's Hospital Harrow UK"},{"name":"Department of Surgery and Cancer Imperial College London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Cavazzoni","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Perugia Perugia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Bradshaw","sequence":"additional","affiliation":[{"name":"St Mark's Hospital Harrow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. F. C.","family":"Lung","sequence":"additional","affiliation":[{"name":"St Mark's Hospital Harrow UK"},{"name":"Department of Surgery and Cancer Imperial College London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Ilangovan","sequence":"additional","affiliation":[{"name":"St Mark's Hospital Harrow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. J.","family":"Vaizey","sequence":"additional","affiliation":[{"name":"St Mark's Hospital Harrow UK"},{"name":"Department of Surgery and Cancer Imperial College London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. D.","family":"Faiz","sequence":"additional","affiliation":[{"name":"St Mark's Hospital Harrow UK"},{"name":"Department of Surgery and Cancer Imperial College London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. L.","family":"Hart","sequence":"additional","affiliation":[{"name":"St Mark's Hospital Harrow UK"},{"name":"Department of Surgery and Cancer Imperial College London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. K.","family":"Clark","sequence":"additional","affiliation":[{"name":"St Mark's Hospital Harrow UK"},{"name":"Department of Surgery and Cancer Imperial College London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03530070057030"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(16)46488-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02234823"},{"key":"e_1_2_9_5_1","first-page":"33","article-title":"Epidemiology of fecal incontinence: the silent affliction","volume":"91","author":"Johanson JF","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6130.85"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/gastro\/gou013"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000427"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e3182272128"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm17135"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-0950-z"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800831226"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200207000-00009"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-1318.2001.00257.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05987.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.1998.00689.x"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.14422","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.14422","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/codi.14422","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.14422","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T11:04:00Z","timestamp":1694430240000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.14422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,8]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1111\/codi.14422"],"URL":"https:\/\/doi.org\/10.1111\/codi.14422","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"type":"print","value":"1462-8910"},{"type":"electronic","value":"1463-1318"}],"subject":[],"published":{"date-parts":[[2018,10,8]]},"assertion":[{"value":"2018-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}