{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T09:02:03Z","timestamp":1784797323404,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2019,2]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>Short\u2010term morbidity and long\u2010term functional outcome of patients with an ileal pouch\u2010anal anastomosis (IPAA<\/jats:styled-content>) exposed to pelvic external beam radiation therapy (EBRT<\/jats:styled-content>) remains unknown. We report the largest series to date regarding the effects of pelvic EBRT<\/jats:styled-content> on: (i) 30\u2010day postoperative outcomes; and (ii) long\u2010term functional outcome following IPAA<\/jats:styled-content>.<\/jats:p><\/jats:sec>Method<\/jats:title>A retrospective chart review was conducted of patients who received EBRT<\/jats:styled-content> before or after IPAA<\/jats:styled-content> between 1980 and 2017 across three international inflammatory bowel disease referral centres.<\/jats:p><\/jats:sec>Results<\/jats:title>Nineteen patients were included. Indications for EBRT<\/jats:styled-content> were rectal adenocarcinoma (n<\/jats:italic>\u00a0=\u00a013), prostate adenocarcinoma (n<\/jats:italic>\u00a0=\u00a04) or anal squamous cell carcinoma (ASCC<\/jats:styled-content>) (n<\/jats:italic>\u00a0=\u00a02). EBRT<\/jats:styled-content> was given prior to IPAA<\/jats:styled-content> in 12 (63%) patients and after IPAA<\/jats:styled-content> in seven (37%). In EBRT<\/jats:styled-content> before IPAA<\/jats:styled-content>, patients had a median of 5 (range: 4\u20138) daytime bowel movements, 1 (range: 0\u20135) night\u2010time bowel movement, no daytime incontinence, and only one patient used pads at a median follow up of 25\u00a0(range: 11\u2013163) months; one patient underwent pouch excision 15\u00a0months after IPAA<\/jats:styled-content>. In EBRT<\/jats:styled-content> after IPAA<\/jats:styled-content>, patients reported a median of 8 (range: 5\u201310) daytime and 2 (range: 0\u20135) night\u2010time bowel movements, 80% had either daytime or night\u2010time incontinence and 80% used pads at a median follow up of 90\u00a0(range: 25\u2013315) months.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Pelvic EBRT<\/jats:styled-content> administered prior to IPAA<\/jats:styled-content> is associated with acceptable long\u2010term function outcome. However, when pelvic EBRT<\/jats:styled-content> is given to an IPAA <\/jats:styled-content>in\u00a0situ<\/jats:italic>, most patients experience poor long\u2010term pouch function without pouch failure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.14467","type":"journal-article","created":{"date-parts":[[2018,11,9]],"date-time":"2018-11-09T09:28:18Z","timestamp":1541755698000},"page":"219-225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Does external beam radiation therapy to the pelvis portend worse ileal pouch outcomes? An international multi\u2010institution collaborative study"],"prefix":"10.1111","volume":"21","author":[{"given":"A. L.","family":"Lightner","sequence":"first","affiliation":[{"name":"Division of Colon and Rectal Surgery Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Spinelli","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University Rozzano Italy"},{"name":"Colon and Rectal Surgery Unit Humanitas Clinical and Research Center Rozzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. P.","family":"McKenna","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. L.","family":"Hallemeier","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Fleshner","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery Cedars\u2010Sinai Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6130.85"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.01.017"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-008-9194-7"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e318246418e"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000206"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-015-0479-4"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-009-0807-y"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-013-1683-z"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2827-z"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prro.2015.03.002"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000001263"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2008.06.052"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2016.12.014"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91510-2"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2002.02196.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)92612-7"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040694"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.8.1008"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.40.1836"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.14467","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.14467","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T12:41:39Z","timestamp":1694695299000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.14467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1111\/codi.14467"],"URL":"https:\/\/doi.org\/10.1111\/codi.14467","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"2018-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}