{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T12:03:49Z","timestamp":1784894629073,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T00:00:00Z","timestamp":1545350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Our goal was to determine the incidence and clinical behaviour of peritoneal metastases (<jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>) in patients with colorectal cancer undergoing potentially curative surgery, comparing patients with extensive locoregional lymph node involvement (<jats:styled-content style=\"fixed-case\">pN<\/jats:styled-content>2) with those who have serosal involvement (<jats:styled-content style=\"fixed-case\">pT<\/jats:styled-content>4), a known risk factor for developing PM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A retrospective analysis of a prospectively maintained database was performed. All patients with <jats:styled-content style=\"fixed-case\">pT<\/jats:styled-content>4 and <jats:styled-content style=\"fixed-case\">pN<\/jats:styled-content>2 were included in the analysis. The diagnostic criteria were the finding of <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content> during surgery with biopsy confirmation as well as imaging features suggestive of <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>, including ovarian metastases and omental deposits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and fourteen patients treated between May 2010 and October 2015 were included. Of these, 110 (51.4%) had <jats:styled-content style=\"fixed-case\">pT<\/jats:styled-content>4 and 131 (61.2%) <jats:styled-content style=\"fixed-case\">pN<\/jats:styled-content>2 tumours: 17.2% of patients with <jats:styled-content style=\"fixed-case\">pT<\/jats:styled-content>4 tumours and 20.2% of patients with <jats:styled-content style=\"fixed-case\">pN<\/jats:styled-content>2 tumours developed <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.53). The median time to detection of <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content> was 16.6\u00a0months and 11.8\u00a0months for <jats:styled-content style=\"fixed-case\">pT<\/jats:styled-content>4 and <jats:styled-content style=\"fixed-case\">pN<\/jats:styled-content>2 tumours, respectively. <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content> were isolated in 51.8% of patients with <jats:styled-content style=\"fixed-case\">pN<\/jats:styled-content>2 tumours. Nonperitoneal metastases developed in 37.5% of patients with <jats:styled-content style=\"fixed-case\">pN<\/jats:styled-content>2 tumours. In <jats:styled-content style=\"fixed-case\">pN<\/jats:styled-content>2 tumours, the incidence of <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content> was higher in signet ring cell and mucinous tumours (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), positive surgical margins (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02), colonic versus rectal tumours (<jats:italic>P<\/jats:italic>\u00a0=\u00a0&lt;\u00a00.01) and right colon primary tumours (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">pN<\/jats:styled-content>2 tumours are at an increased risk of developing <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>, which is similar to the risk in <jats:styled-content style=\"fixed-case\">pT<\/jats:styled-content>4 tumours. <jats:styled-content style=\"fixed-case\">pN<\/jats:styled-content>2 tumours should be included in clinical trials evaluating preventive\/proactive strategies. There is a need to identify predictive biomarkers for the development of <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content> versus other sites of metastasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.14481","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T12:04:15Z","timestamp":1542715455000},"page":"287-296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Patients with extensive regional lymph node involvement (<scp>pN<\/scp>2) following potentially curative surgery for colorectal cancer are at increased risk for developing peritoneal metastases: a retrospective single\u2010institution study"],"prefix":"10.1111","volume":"21","author":[{"given":"A.","family":"Bhatt","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology Zydus Hospital Ahmedabad 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