{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T17:58:24Z","timestamp":1779904704686,"version":"3.53.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T00:00:00Z","timestamp":1546214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Intersphincteric resection (<jats:styled-content style=\"fixed-case\">ISR<\/jats:styled-content>) is an advanced anus\u2010preserving operation for treating low rectal cancer while avoiding colostomy. High\u2010resolution anorectal manometry (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ARM<\/jats:styled-content>) allows objective and accurate evaluation of anal function. However, correlations between anal function after <jats:styled-content style=\"fixed-case\">ISR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ARM<\/jats:styled-content> parameters are unknown. The aim of the study was to evaluate <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ARM<\/jats:styled-content> for objective evaluation of anal function after <jats:styled-content style=\"fixed-case\">ISR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A total of 81 patients who underwent <jats:styled-content style=\"fixed-case\">ISR<\/jats:styled-content> at our hospital between October 2014 and March 2016 were identified from our prospectively collected database and electronic medical records. Of these, 68 patients who had been evaluated using <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ARM<\/jats:styled-content> both before and after <jats:styled-content style=\"fixed-case\">ISR<\/jats:styled-content> were included in the study. Faecal incontinence (<jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content>) was assessed by Wexner score. Multivariate analysis was performed to determine risk factors for severe <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content> after <jats:styled-content style=\"fixed-case\">ISR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Maximum resting pressure (<jats:styled-content style=\"fixed-case\">MRP<\/jats:styled-content>) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and maximum squeeze pressure (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04) were significantly lower after <jats:styled-content style=\"fixed-case\">ISR<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">MRP<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and maximum squeeze pressure (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02) were significantly lower after total (or subtotal) <jats:styled-content style=\"fixed-case\">ISR<\/jats:styled-content> than after partial <jats:styled-content style=\"fixed-case\">ISR<\/jats:styled-content>. The overall incidence of severe <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content> after <jats:styled-content style=\"fixed-case\">ISR<\/jats:styled-content> was 18% (12\/68), and a high pressure zone before <jats:styled-content style=\"fixed-case\">ISR<\/jats:styled-content> \u2264\u00a03\u00a0cm (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.007) and <jats:styled-content style=\"fixed-case\">MRP<\/jats:styled-content> before <jats:styled-content style=\"fixed-case\">ISR<\/jats:styled-content> &gt;\u00a060\u00a0mmHg (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02) were independently associated with an elevated incidence of severe <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content> after <jats:styled-content style=\"fixed-case\">ISR<\/jats:styled-content>. Decreased preoperative <jats:styled-content style=\"fixed-case\">MRP<\/jats:styled-content> also correlated with severe <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content> after <jats:styled-content style=\"fixed-case\">ISR<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.008).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ARM<\/jats:styled-content> is reliable for the evaluation of anal function after <jats:styled-content style=\"fixed-case\">ISR<\/jats:styled-content>, and the high pressure zone and <jats:styled-content style=\"fixed-case\">MRP<\/jats:styled-content> may be useful preoperative predictors of severe <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content> after <jats:styled-content style=\"fixed-case\">ISR<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.14528","type":"journal-article","created":{"date-parts":[[2018,12,8]],"date-time":"2018-12-08T08:54:26Z","timestamp":1544259266000},"page":"335-341","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Clinical benefit of high resolution anorectal manometry for the evaluation of anal function after intersphincteric resection"],"prefix":"10.1111","volume":"21","author":[{"given":"D.","family":"Kitaguchi","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery National Cancer Center Hospital East Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Nishizawa","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery National Cancer Center Hospital East Chiba 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