{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:35:42Z","timestamp":1792643742338,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,2]],"date-time":"2019-02-02T00:00:00Z","timestamp":1549065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Whether some diseases are related to the occurrence of synchronous colorectal carcinoma (<jats:styled-content style=\"fixed-case\">sCRC<\/jats:styled-content>) is unknown. Investigating the risk factors and presentation of <jats:styled-content style=\"fixed-case\">sCRC<\/jats:styled-content> could aid in the treatment of patients with colorectal cancer (<jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>). The prognosis of <jats:styled-content style=\"fixed-case\">sCRC<\/jats:styled-content> compared with that of solitary <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 17\u00a0093 <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> patients were recruited between 1st January 1995 and 31th December 2016. The risk factors of <jats:styled-content style=\"fixed-case\">sCRC<\/jats:styled-content> development were assessed using univariate and multivariate logistic regression. The effect of <jats:styled-content style=\"fixed-case\">sCRC<\/jats:styled-content> on survival was analysed using the multivariate Cox regression model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of <jats:styled-content style=\"fixed-case\">sCRC<\/jats:styled-content> was 5.6% in this study. The independent risk factors of <jats:styled-content style=\"fixed-case\">sCRC<\/jats:styled-content> development were advanced age (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001), male sex (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001), hereditary cancer (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001), hypertension (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001) and liver cirrhosis (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.024). Compared with solitary <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>, a higher number of patients with <jats:styled-content style=\"fixed-case\">sCRC<\/jats:styled-content> presented with an abnormal carcinoembryonic antigen (<jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content>) level (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.011), anaemia (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001) and hypoalbuminemia (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). Multivariate analysis revealed that <jats:styled-content style=\"fixed-case\">sCRC<\/jats:styled-content> was a significant factor for poor survival in patients at TNM Stage I [hazard ratio (HR)\u00a0=\u00a01.86; <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001], Stage <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0= 1.65; <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001) and Stage <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a01.40; <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In addition to hypertension and liver cirrhosis, other risk factors for <jats:styled-content style=\"fixed-case\">sCRC<\/jats:styled-content> were identified in this study. The prognosis of patients with <jats:styled-content style=\"fixed-case\">sCRC<\/jats:styled-content> was significantly worse than that of those with solitary <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> through TNM Stages I to <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>. Anaemia, abnormal <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content> and hypoalbuminemia were more commonly seen in patients with <jats:styled-content style=\"fixed-case\">sCRC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.14539","type":"journal-article","created":{"date-parts":[[2018,12,22]],"date-time":"2018-12-22T18:23:26Z","timestamp":1545503006000},"page":"432-440","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Synchronous colorectal carcinoma: predisposing factors and characteristics"],"prefix":"10.1111","volume":"21","author":[{"given":"C.\u2010C.","family":"Chin","sequence":"first","affiliation":[{"name":"Division of Colon and Rectal Surgery Department of Surgery Chang Gung Memorial Hospital Chiayi Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010H.","family":"Kuo","sequence":"additional","affiliation":[{"name":"Division of Colon and 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