{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:17:59Z","timestamp":1790673479238,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,2,16]],"date-time":"2019-02-16T00:00:00Z","timestamp":1550275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000589","name":"Chief Scientist Office","doi-asserted-by":"publisher","award":["CZH\/4\/986"],"award-info":[{"award-number":["CZH\/4\/986"]}],"id":[{"id":"10.13039\/501100000589","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Rectal cancer patients undergoing neoadjuvant chemoradiotherapy (NACRT) experience physical deterioration and reductions in their quality of life. This feasibility study assessed prehabilitation (a walking intervention) before, during and after NACRT to inform a definitive multi\u2010centred randomized clinical trial (REx trial).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients planned for NACRT followed by potentially curative surgery were approached (August 2014\u2013March 2016) (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.isrctn.com\">www.isrctn.com<\/jats:ext-link>\n                      ; 62859294). Prior to NACRT, baseline physical and psycho\u2010social data were recorded using validated tools. Participants were randomized to either the intervention group (exercise counselling session followed by a 13\u201317 week telephone\u2010guided walking programme) or a control group (standard care). Follow\u2010up testing was undertaken 1\u20132 weeks before surgery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 296 screened patients, 78 (26%) were eligible and 48 (61%) were recruited.\n                      <jats:italic>N<\/jats:italic>\n                      = 31 (65%) were men with a mean age of 65.9 years (range 33.7\u201382.6). Mean intervention duration was 14 weeks with 75% adherence.\n                      <jats:italic>n<\/jats:italic>\n                      = 40 (83%) completed follow\u2010up testing. Both groups recorded reductions in daily walking but the reduction was less in the intervention group although not statistically significant. Participants reported high satisfaction and fidelity to trial procedures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates that prehabilitation is feasible in rectal cancer patients undergoing NACRT. Good recruitment, adherence, retention and patient satisfaction rates support the development of a fully powered trial. The effects of the intervention on physical outcomes were promising.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.14560","type":"journal-article","created":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T07:54:39Z","timestamp":1547798079000},"page":"548-562","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":99,"title":["Prehabilitation is feasible in patients with rectal cancer undergoing neoadjuvant chemoradiotherapy and may minimize physical deterioration: results from the REx trial"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9969-9760","authenticated-orcid":false,"given":"S. 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