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Our study aimed to review the evidence by conducting a dose\u2013response meta\u2010analysis to investigate this association.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched PubMed and Embase databases for relevant studies published until May 2017. Traditional and dose\u2013response meta\u2010analyses were conducted. Sensitivity analysis was performed to evaluate the robustness of the results. Cumulative meta\u2010analysis was used to assess the risk of different oral contraceptive formulations or generations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 19 observational studies, with 21\u00a0923 CRA cases and 1\u00a0030\u00a0711 participants, were included in the meta\u2010analysis. Ever HRT use showed a potential inverse association with CRA risk [relative risk (RR) 0.83, 95% CI 0.70\u20131.00]. The dose\u2013response meta\u2010analysis further demonstrated that HRT use could reduce CRA risk. Compared with no HRT use, the predicted RRs were 0.82 (95% CI 0.67\u20130.99), 0.76 (95% CI 0.59\u20130.98) and 0.77 (95% CI 0.62\u20130.96) for 3, 6 and 9\u00a0years of HRT use, respectively. All other factors were not statistically significantly associated with CRA risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study indicated that only HRT use might reduce the risk of developing CRA. Any advice regarding HRT use to prevent CRA should be tailored to the individual risks and potential benefits. Large, well\u2010designed prospective studies with long\u2010term follow\u2010up are required to further clarify the aetiology of CRA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.14582","type":"journal-article","created":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T19:55:51Z","timestamp":1550001351000},"page":"748-759","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Hormone replacement therapies, oral contraceptives, reproductive factors and colorectal adenoma risk: a systematic review and dose\u2013response meta\u2010analysis of observational studies"],"prefix":"10.1111","volume":"21","author":[{"given":"J.","family":"Song","sequence":"first","affiliation":[{"name":"Department of Health Statistics Second Military Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Health 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