{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T22:11:04Z","timestamp":1771971064403,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T00:00:00Z","timestamp":1554681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To demonstrate the quality improvement associated with the implementation of a specialist family history of bowel cancer service in secondary care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The following outcomes were assessed: (1) adherence to the British Society of Gastroenterology (<jats:styled-content style=\"fixed-case\">BSG<\/jats:styled-content>) guidelines for colonoscopic surveillance of individuals with a family history of colorectal cancer (CRC); (2) adherence to the revised Bethesda criteria for the identification of CRC patients with suspected Lynch syndrome; (3) identification of inherited syndromes with increased CRC risk; and (4) colonoscopic adenoma detection rate. Data were collected for a 21\u2010month period before and after the establishment of this service for all patients who underwent colonoscopic surveillance for a family history of CRC and all patients newly diagnosed with CRC. Analyses compared the number of colonoscopies performed that were not indicated by <jats:styled-content style=\"fixed-case\">BSG<\/jats:styled-content> guidelines, the average number of years early that patients were screened, the adenoma detection rate and the rate of tumour testing for mismatch repair genes before and after the implementation of the service.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Following the establishment of the service there was a reduction in the number of colonoscopies not indicated by <jats:styled-content style=\"fixed-case\">BSG<\/jats:styled-content> guidelines (39.6% before and 5.8% after, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001, chi\u2010square test) and surveillance colonoscopy took place at a more appropriate age (10.6 years too early before and 5.9\u00a0years early after, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.01, <jats:italic>t<\/jats:italic>\u2010test). There was an increased adenoma detection rate (17% before and 31.9% after, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01, chi\u2010square test) and increased tumour <jats:styled-content style=\"fixed-case\">MMR<\/jats:styled-content> testing (3.4% before and 91.8% after, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01, chi\u2010square test).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The introduction of a family history of bowel cancer service results in improved patient care through improved adherence to guidelines for colonoscopic surveillance and increased cancer detection rates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.14622","type":"journal-article","created":{"date-parts":[[2019,3,23]],"date-time":"2019-03-23T13:50:24Z","timestamp":1553349024000},"page":"879-885","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A dedicated high\u2010quality service for the management of patients with an inherited risk of colorectal cancer"],"prefix":"10.1111","volume":"21","author":[{"given":"L. K.","family":"Adams","sequence":"first","affiliation":[{"name":"Chelsea and Westminster NHS Trust West Middlesex University Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Qiu","sequence":"additional","affiliation":[{"name":"Imperial College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. K.","family":"Hunt","sequence":"additional","affiliation":[{"name":"Chelsea and Westminster NHS Trust West Middlesex University Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7918-4003","authenticated-orcid":false,"given":"K. J.","family":"Monahan","sequence":"additional","affiliation":[{"name":"Imperial College London London UK"},{"name":"Family History of Bowel Cancer Clinic Chelsea and Westminster NHS Trust West Middlesex University Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,8]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Cancer Research UK.Bowel Cancer Incidence Statistics[internet].London UK:Cancer Research UK 2015.https:\/\/www.cancerresearchuk.org\/health-professional\/cancer-statistics\/statistics-by-cancer-type\/bowel-cancer\/incidence(accessed October 2018)."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200007133430201"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh034"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta18580"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro-2013-100362"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.179804"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-017-0062-2"},{"key":"e_1_2_8_9_1","unstructured":"National Institute for Health and Clinical Excellence.Molecular testing strategies for Lynch syndrome in people with colorectal cancer 2017.https:\/\/www.nice.org.uk\/guidance\/dg27(accessed October 2018)."},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro-2013-100345"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2009.01871.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.12117"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.04.044"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9316"},{"key":"e_1_2_8_15_1","unstructured":"National Bowel Cancer Audit.Leeds UK:National Bowel Cancer Audit 2019.https:\/\/www.nboca.org.uk\/(accessed January 2019)."},{"key":"e_1_2_8_16_1","unstructured":"London Cancer Alliance.LCA Colorectal Cancer Clinical Guidelines.London UK:London Cancer Alliance 2014. pp.63.http:\/\/www.londoncanceralliance.nhs.uk\/media\/83350\/lca_colorectalclinicalguidelines2014.pdf(accessed October 2018)."},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2007.01257.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(04)00352-0"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e31827edfff"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2008.01644.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-006-9000-4"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200603000-00004"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-155-2-201107190-00002"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-5908-5-6"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.14622","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.14622","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/codi.14622","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.14622","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T15:36:47Z","timestamp":1694273807000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.14622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,8]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1111\/codi.14622"],"URL":"https:\/\/doi.org\/10.1111\/codi.14622","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,8]]},"assertion":[{"value":"2018-11-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}