{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T04:34:56Z","timestamp":1768710896820,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T00:00:00Z","timestamp":1560211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005940","name":"Dansk Kr\u00e6ftforsknings Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005940","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this investigation was to examine quality of life after surgical treatment for low rectal cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This was a population\u2010based, cross\u2010sectional study on quality of life in patients treated for rectal cancer from 2001 to 2007. The European Organization for Research and Treatment of Cancer (<jats:styled-content style=\"fixed-case\">EORTC<\/jats:styled-content>) Quality of Life Questionnaire (<jats:styled-content style=\"fixed-case\">QLQ<\/jats:styled-content>\u2010C30) and a single question on the impact of bowel\/stoma function on quality of life were sent to patients who had undergone abdominoperineal excision (<jats:styled-content style=\"fixed-case\">APE<\/jats:styled-content>) or low anterior resection (<jats:styled-content style=\"fixed-case\">LAR<\/jats:styled-content>) for rectal cancer with tumours below 10\u00a0cm from the anal verge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Informative answers were obtained from 898 patients (87%). <jats:styled-content style=\"fixed-case\">EORTC QLQ<\/jats:styled-content>\u2010C30 outcomes were very similar for <jats:styled-content style=\"fixed-case\">APE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LAR<\/jats:styled-content> patients in univariate analysis. When adjusted for neoadjuvant radiotherapy and gender, multivariate analysis showed that <jats:styled-content style=\"fixed-case\">LAR<\/jats:styled-content> patients had lower global health status (OR 1.32, 95% CI 1.03; 1.68, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.026) and higher occurrence of constipation (OR 0.47, 95% CI 0.32; 0.69, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and diarrhoea (OR 0.47, 95% CI 0.35; 0.64, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Analysis of the anchor question showed that <jats:styled-content style=\"fixed-case\">LAR<\/jats:styled-content> patients had significantly higher negative impact of bowel function on quality of life in both univariate (OR 3.38, 95% CI 2.62; 4.37, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and multivariate analysis (OR 3.71, 95% CI 2.86; 4.83, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) compared with <jats:styled-content style=\"fixed-case\">APE<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For patients with low rectal cancer, we found <jats:styled-content style=\"fixed-case\">LAR<\/jats:styled-content> patients had worse global health status and problems with diarrhoea and constipation compared with <jats:styled-content style=\"fixed-case\">APE<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.14684","type":"journal-article","created":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T06:13:10Z","timestamp":1557468790000},"page":"1051-1057","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Quality of life with or without sphincter preservation for rectal cancer"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2307-4953","authenticated-orcid":false,"given":"M.\u2010L.","family":"Feddern","sequence":"first","affiliation":[{"name":"Surgical Department Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. 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