{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T17:03:19Z","timestamp":1772038999919,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T00:00:00Z","timestamp":1559088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Colon ischaemia (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) is most commonly an acute and reversible manifestation of a transient, non\u2010occlusive decrease of blood flow in the colonic microvasculature. Irreversible complications are uncommon and the progression to chronic <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> remains controversial. Our objective was to identify cases of chronic <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> and assess for distinct clinicopathological features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A retrospective review was performed of <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> patients having symptom chronicity of \u2265\u00a01\u00a0month and ischaemic histology at our institution from 1994 to 2015. Demographic, clinical, endoscopic, radiological, pathological and outcome variables were abstracted. Histological evaluation was performed by two gastrointestinal pathologists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a09; 67% men) with a median age of 65\u00a0years (range 22\u201388) were identified. The most common presenting symptoms were diarrhoea and abdominal pain (<jats:italic>n<\/jats:italic>\u00a0=\u00a06, 86%; <jats:italic>n<\/jats:italic>\u00a0=\u00a05, 71%, respectively). The typical endoscopic appearance was segmental ulceration of the sigmoid colon (<jats:italic>n<\/jats:italic>\u00a0=\u00a06, 75%). Vascular imaging showed patent mesenteric vessels in all patients. Histopathological evaluation revealed venous intimal hyperplasia consistent with idiopathic myointimal hyperplasia of the mesenteric veins (<jats:styled-content style=\"fixed-case\">IMHMV<\/jats:styled-content>) in eight patients; the remainder showed non\u2010specific ulceration and fibrosis. Surgical resection was performed in seven <jats:styled-content style=\"fixed-case\">IMHMV<\/jats:styled-content> patients, resulting in symptom resolution. On re\u2010review of pre\u2010resection biopsies, all <jats:styled-content style=\"fixed-case\">IMHMV<\/jats:styled-content> patients had characteristic changes of hyperplastic, thick\u2010walled, hyalinized vessels in the lamina propria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>IMHMV is a unique histopathological entity causing chronic <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>. The small vessel histological changes in <jats:styled-content style=\"fixed-case\">IMHMV<\/jats:styled-content> are distinctive in colonic resections and undetectable by routine vascular imaging. Preoperative diagnosis of <jats:styled-content style=\"fixed-case\">IMHMV<\/jats:styled-content> is possible with endoscopic biopsy and segmental colon resection is curative.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.14685","type":"journal-article","created":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T09:03:35Z","timestamp":1557479015000},"page":"1073-1078","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Idiopathic myointimal hyperplasia is a distinct cause of chronic colon ischaemia"],"prefix":"10.1111","volume":"21","author":[{"given":"B.","family":"Anderson","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic College of Medicine Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. C.","family":"Smyrk","sequence":"additional","affiliation":[{"name":"Division of Anatomic Pathology Mayo Clinic College of Medicine Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. P.","family":"Graham","sequence":"additional","affiliation":[{"name":"Division of Anatomic Pathology Mayo Clinic College of Medicine Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Lightner","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery Mayo Clinic College of Medicine Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Sweetser","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic College of Medicine Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.70.11.920"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afh226"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000290"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.395"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02236711"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90035-J"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00663-2"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1291529"},{"key":"e_1_2_8_10_1","first-page":"696","article-title":"Refractory pancolitis: a novel presentation of idiopathic myointimal hyperplasia of mesenteric veins","volume":"8","author":"Korenblit J","year":"2012","journal-title":"Gastroenterol Hepatol"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12470"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200509000-00011"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00014"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.14685","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.14685","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/codi.14685","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.14685","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T07:32:11Z","timestamp":1694331131000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.14685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,29]]},"references-count":12,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1111\/codi.14685"],"URL":"https:\/\/doi.org\/10.1111\/codi.14685","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,29]]},"assertion":[{"value":"2019-01-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}