{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T23:40:17Z","timestamp":1784590817715,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T00:00:00Z","timestamp":1559692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to assess the value of positron emission tomography (<jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>)\/<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> and sentinel lymph node (<jats:styled-content style=\"fixed-case\">SLN<\/jats:styled-content>) biopsy in staging inguinal lymph nodes in anal cancer patients and to determine if the results of the two methods could be of prognostic value.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Sixty\u2010three patients with anal cancer and clinically negative inguinal lymph nodes underwent lymphoscintigraphy and inguinal <jats:styled-content style=\"fixed-case\">SLN<\/jats:styled-content> biopsy and\/or fluorodeoxyglucose (<jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> scan. All patients were treated with radiotherapy combined with 5\u2010fluorouracil and mitomycin\u2010C.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) and disease\u2010free survival (<jats:styled-content style=\"fixed-case\">DFS<\/jats:styled-content>) were 43\u00a0months (range 5\u2013211) and 43\u00a0months (range 4\u2013142) respectively. <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> examination showed high <jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content> uptake in the inguinal lymph nodes in 25% of patients. Thirty\u2010five patients with inguinal uptake at lymphoscintigraphy underwent inguinal <jats:styled-content style=\"fixed-case\">SLN<\/jats:styled-content> biopsy and metastatic nodes were found in 31.4%. There was no statistical difference in <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> (55 <jats:italic>vs<\/jats:italic> 41\u00a0months; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.652) and <jats:styled-content style=\"fixed-case\">DFS<\/jats:styled-content> (48 <jats:italic>vs<\/jats:italic> 38\u00a0months; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.992) between the group which showed inguinal uptake on <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> and the group which did not, while a positive inguinal SLN was associated with a worse <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> (28 <jats:italic>vs<\/jats:italic> 59 months; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.028) and <jats:styled-content style=\"fixed-case\">DFS<\/jats:styled-content> (56 <jats:italic>vs<\/jats:italic> 21 months; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.046). When the two examinations were compared <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> showed a sensitivity, specificity, positive predictive value and negative predictive value of 22%, 82%, 33% and 73% respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The technique of <jats:styled-content style=\"fixed-case\">SLN<\/jats:styled-content> biopsy had a better diagnostic accuracy than total body <jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> for the staging of inguinal lymph nodes in anal cancer patients; moreover it was a stronger predictor of <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DFS<\/jats:styled-content> than <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.14691","type":"journal-article","created":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T13:57:51Z","timestamp":1557583071000},"page":"1017-1024","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Prognostic value of fluorodeoxyglucose positron emission tomography\/computed tomography and inguinal sentinel lymph node biopsy in patients with anal cancer"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9337-6765","authenticated-orcid":false,"given":"P.","family":"De Nardi","sequence":"first","affiliation":[{"name":"Gastrointestinal Surgery San Raffaele Scientific Institute Milan 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