{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:38:25Z","timestamp":1769819905960,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T00:00:00Z","timestamp":1562025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Postoperative pain remains a major factor in recovery from colorectal resection. There is increasing interest in opioid\u2010sparing analgesia, and intraperitoneal local anaesthetic (IPLA) has recently been shown to be useful in minor laparoscopic and open colorectal procedures. The aim of this study was to evaluate the impact of IPLA on functional recovery following major laparoscopic surgery. In this controlled trial, mobility, as measured by the De Morton Mobility Index (DEMMI), was used as a surrogate for postoperative functional recovery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Patients undergoing laparoscopic colorectal resection were randomized either to continuous ropivacaine (0.2% at 4\u20136\u00a0ml\/h) or to saline (0.9%) which were administered via intraperitoneal catheter for 3\u00a0days postoperatively. Results were analysed in a double\u2010blind manner. DEMMIs were assessed on postoperative days 1, 2, 3, 7 and 30, and data on pain, opioid consumption, gut and respiratory function, length of stay (LOS) and complications were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010six patients were recruited. There was no difference in primary outcome (i.e., functional recovery) between IPLA and placebo groups. Opioid consumption and LOS were similar between groups, and no differences were found for any secondary outcome measure. There were no adverse events related to ropivacaine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Infusional intraperitoneal local anaesthetic appears to be safe but does not improve functional recovery or analgesic consumption following elective laparoscopic colorectal surgery, in the setting of an established enhanced recovery programme.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.14720","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T17:46:14Z","timestamp":1558633574000},"page":"1183-1191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The LAPLAP study: a randomized placebo\u2010controlled clinical trial assessing postoperative functional recovery using intraperitoneal local anaesthetic in laparoscopic colorectal surgery"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6287-7794","authenticated-orcid":false,"given":"B. D.","family":"Stephensen","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery John Hunter Hospital Newcastle New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Clarke","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery John Hunter Hospital Newcastle New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"McManus","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery John Hunter Hospital Newcastle New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery John Hunter Hospital Newcastle New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Carroll","sequence":"additional","affiliation":[{"name":"Department of Surgery John Hunter Hospital Newcastle New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Holz","sequence":"additional","affiliation":[{"name":"Newcastle Anaesthetic and Perioperative Service Newcastle New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. R.","family":"Smith","sequence":"additional","affiliation":[{"name":"University of Newcastle Newcastle New South Wales Australia"},{"name":"Hunter Surgical Clinical Research Unit Department of Colorectal Surgery John Hunter Hospital Newcastle New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0b013e3282f0c005"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-198510000-00005"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0b013e3283261b53"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000130260.24433.A2"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-6516-2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318221f0cf"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2010.03.024"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000001177"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2318-10-72"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181b13ca2"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.14317"},{"key":"e_1_2_9_14_1","first-page":"CD003432","article-title":"Long\u2010term results of laparoscopic colorectal cancer resection","volume":"2","author":"Kuhry E","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09290-5"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-009-0382-y"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2007.12.011"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31824babfe"},{"key":"e_1_2_9_19_1","first-page":"660","article-title":"Ropivacaine inhibits serum\u2010induced proliferation of colon adenocarcinoma cells in vitro","volume":"288","author":"Martinsson T","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2007.036"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026013395164"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-6612.2010.00497.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.2340\/16501977-0626"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1836-9553(11)70021-2"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2010.08.023"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2015.02.015"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/09638288.2014.982832"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.14555"},{"key":"e_1_2_9_29_1","unstructured":"HolmesR SmithSR CarrollR PockneyP.Validation of a mobility assessment tool in gastrointestinal surgical patients. Podium presentation Surgical Research Society ASM 14th Nov 2014.Adelaide Australia 2014."}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.14720","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.14720","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/codi.14720","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.14720","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T08:11:31Z","timestamp":1694247091000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.14720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,2]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1111\/codi.14720"],"URL":"https:\/\/doi.org\/10.1111\/codi.14720","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,2]]},"assertion":[{"value":"2019-01-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}