{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T16:23:30Z","timestamp":1772641410822,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T00:00:00Z","timestamp":1565136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Human papillomavirus (<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>)\u2010related anal squamous cell dysplasia has been well\u2010reported in high\u2010risk (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) patients [human immunodeficiency virus (<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>)\u2010positive, men having sex with men (<jats:styled-content style=\"fixed-case\">MSM<\/jats:styled-content>) or immune\u2010suppressed transplant recipients]. However, data are extremely limited for all other patients. This study reports treatment outcomes for <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010related dysplasia in a population of non\u2010<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A retrospective study was performed to review treatment efficacy in non\u2010<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> patients diagnosed with anal dysplasia or superficially invasive squamous cell carcinoma of the anus (<jats:styled-content style=\"fixed-case\">SISCCA<\/jats:styled-content>) with at least 12\u2010months\u2019 follow\u2010up; <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> patients were excluded. Medical records were reviewed for demographics, pathology, cytopathology, treatment and recurrences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010one patients were identified (34 women). The median age at diagnosis was 58\u00a0years (range 26\u201385) and median follow\u2010up was 26\u00a0months (range 12\u201351). At diagnosis, 36 patients had anal dysplasia and five patients had <jats:styled-content style=\"fixed-case\">SISCCA<\/jats:styled-content>. Treatment outcomes (resolved versus recurrent) differed between treatment modalities (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.014). Topical and fulguration\u2010only treatment modalities were superior to wide local excision (<jats:styled-content style=\"fixed-case\">WLE<\/jats:styled-content>) (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.006 and <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.008, respectively). Fourteen (39%) patients had recurrent dysplasia at a median of 14\u00a0months (range 4\u201362); eight patients developed a second recurrence at a median of 14\u00a0months (range 11\u201326). No <jats:styled-content style=\"fixed-case\">SISCCA<\/jats:styled-content> patient had a recurrence, but two patients progressed to anal cancer after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The behaviour of anal dysplasia reported in this under\u2010represented, small group of non\u2010<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> patients reveals that treatment for anal dysplasia is not necessarily a single event and nonexcisional treatments may be favourable to <jats:styled-content style=\"fixed-case\">WLE<\/jats:styled-content>. Though the true denominator of this population is unknown, treatment may not prevent the recurrence of dysplasia or progression to cancer, warranting close follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.14786","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T20:03:20Z","timestamp":1564085000000},"page":"29-35","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Treatment efficacy for human papillomavirus\u2010related anal squamous cell dysplasia in an under\u2010represented population: human immunodeficiency\u2010negative, non\u2010men having sex with men, and non\u2010transplant population"],"prefix":"10.1111","volume":"22","author":[{"given":"C. A.","family":"Messick","sequence":"first","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,7]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"NC Institute.Surveillance Epidemiology and End Results Stat Fact Sheets: Anal Cancer. [Webpage] 2018.https:\/\/seer.cancer.gov(accessed December 2018)."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21442"},{"key":"e_1_2_7_4_1","volume-title":"SEER Cancer Statistics Review","author":"Howlader N","year":"2016"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-149-5-200809020-00004"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e31826916c7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e31825c31dd"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3182437469"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e318227833e"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-018-0273-9"},{"key":"e_1_2_7_11_1","first-page":"31","article-title":"Anal intraepitelial neoplasia: a narrative review","volume":"108","author":"Elorza G","year":"2016","journal-title":"Rev Esp Enferm Dig"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soc.2016.07.005"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800810313"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-007-0262-4"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000058"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.12951"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy273"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e31819793d9"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.14786","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.14786","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/codi.14786","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.14786","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T13:10:21Z","timestamp":1694092221000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.14786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,7]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1111\/codi.14786"],"URL":"https:\/\/doi.org\/10.1111\/codi.14786","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,7]]},"assertion":[{"value":"2019-02-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}