{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T04:57:40Z","timestamp":1769230660703,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T00:00:00Z","timestamp":1570060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite implementation of enhanced recovery after surgery (<jats:styled-content style=\"fixed-case\">ERAS<\/jats:styled-content>) and laparoscopic techniques, postoperative ileus (<jats:styled-content style=\"fixed-case\">POI<\/jats:styled-content>) remains frequent after colorectal surgery, impacting the patient, their recovery and health\u2010care resources. Presently there are no tests that reliably predict or enable early POI diagnosis. Volatile organic compounds (VC) are products of human and microbiota cellular metabolism and we hypothesised that a detectable alteration occurs in POI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This was a prospective observational study of patients undergoing laparoscopic colorectal resection within an established <jats:styled-content style=\"fixed-case\">ERAS<\/jats:styled-content> programme. Standardized end\u2010expiratory breath sampling was performed on the morning of surgery and on the first three postoperative mornings. The concentrations of VCs commonly found in intestinal gas were analysed using selected ion flow tube mass spectrometry and Gastro<jats:styled-content style=\"fixed-case\">CH<\/jats:styled-content><jats:sub>4<\/jats:sub><jats:styled-content style=\"fixed-case\">ECK<\/jats:styled-content>\u00ae. Feasibility data, bowel preparation, postoperative oral intake, <jats:styled-content style=\"fixed-case\">POI<\/jats:styled-content> and 30\u2010day morbidity were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 75 potentially eligible patients, 58 (77%) agreed to participate. Per\u2010protocol breath sampling was successfully completed in 94%. There were no analytical failures. Baseline and postoperative concentrations of <jats:styled-content style=\"fixed-case\">VC<\/jats:styled-content>s were broadly comparable and were not altered by bowel preparation or postoperative oral intake. <jats:styled-content style=\"fixed-case\">POI<\/jats:styled-content> developed in 14 (29%) patients. Preoperative ammonia concentration was higher in patients who developed <jats:styled-content style=\"fixed-case\">POI<\/jats:styled-content> [830\u00a0parts per billion (ppb) <jats:italic>vs<\/jats:italic> 510\u00a0ppb, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.027]. There was an increase in the concentration of acetic acid detected on day 2 in patients who developed <jats:styled-content style=\"fixed-case\">POI<\/jats:styled-content> (99\u00a0ppb <jats:italic>vs<\/jats:italic> 171\u00a0ppb, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.021).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Repeated <jats:styled-content style=\"fixed-case\">VC<\/jats:styled-content> breath sampling and analysis is feasible in the perioperative setting. An elevated ammonia concentration on the morning of surgery may be a potential predictor of <jats:styled-content style=\"fixed-case\">POI<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.14788","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T20:10:40Z","timestamp":1564085440000},"page":"86-94","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Feasibility of perioperative volatile organic compound breath testing for prediction of paralytic ileus following laparoscopic colorectal resection"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8498-9175","authenticated-orcid":false,"given":"N. K.","family":"Francis","sequence":"first","affiliation":[{"name":"Department of General Surgery Yeovil District Hospital NHS Foundation Trust Yeovil UK"},{"name":"Faculty of Science University of Bath Bath UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5655-6823","authenticated-orcid":false,"given":"N. J.","family":"Curtis","sequence":"additional","affiliation":[{"name":"Department of General Surgery Yeovil District Hospital NHS Foundation Trust Yeovil UK"},{"name":"Department of Surgery and Cancer Imperial College London, Level 10 St Mary's Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Salib","sequence":"additional","affiliation":[{"name":"Faculty of Health and Life Sciences University of Liverpool Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"de Lacy Costello","sequence":"additional","affiliation":[{"name":"Institute of Bio\u2010Sensing Technology University of the West of England Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. M.","family":"Lemm","sequence":"additional","affiliation":[{"name":"Department of General Surgery Yeovil District Hospital NHS Foundation Trust Yeovil UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Gould","sequence":"additional","affiliation":[{"name":"Institute of Bio\u2010Sensing Technology University of the West of England Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Crilly","sequence":"additional","affiliation":[{"name":"Department of General Surgery Yeovil District Hospital NHS Foundation Trust Yeovil UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Allison","sequence":"additional","affiliation":[{"name":"Department of General Surgery Yeovil District Hospital NHS Foundation Trust Yeovil UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Ratcliffe","sequence":"additional","affiliation":[{"name":"Institute of Bio\u2010Sensing Technology 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