{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:48:56Z","timestamp":1784292536380,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T00:00:00Z","timestamp":1566345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The low anterior resection syndrome (<jats:styled-content style=\"fixed-case\">LARS<\/jats:styled-content>) severely affects quality of life (QoL) after colorectal cancer surgery. There are no data about these complaints and the association with QoL in a reference population. The aim of this study was to assess <jats:styled-content style=\"fixed-case\">LARS<\/jats:styled-content> and the association with QoL in a reference population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six hundred patients who visited the outpatient clinic because of general or trauma surgical indications were asked to participate in this study. They received an invitation letter containing three validated questionnaires to assess <jats:styled-content style=\"fixed-case\">LARS<\/jats:styled-content> (assessed with the LARS score) and both general [European Organization for the Research and Treatment of Cancer (<jats:styled-content style=\"fixed-case\">EORTC<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">QLQ<\/jats:styled-content>\u2010C30] and colorectal\u2010specific (<jats:styled-content style=\"fixed-case\">EORTC QLQ<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>29) QoL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five hundred and one respondents could be included for the analyses. The median age at inclusion was 68\u00a0years and 47.3% were men. Major <jats:styled-content style=\"fixed-case\">LARS<\/jats:styled-content> was observed in 15% of patients (11.4% in men and 18.9% in women, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.021). Women reported more urgency (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.070) and incontinence for both flatus (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and stool (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.063) compared to men. In univariate analyses, women reported major <jats:styled-content style=\"fixed-case\">LARS<\/jats:styled-content> significantly more often than men (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a01.82; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.10\u20133.01). Patients with major <jats:styled-content style=\"fixed-case\">LARS<\/jats:styled-content> scored significantly worse in most QoL domains compared to patients with no\/minor <jats:styled-content style=\"fixed-case\">LARS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first study demonstrating major <jats:styled-content style=\"fixed-case\">LARS<\/jats:styled-content> and the association with QoL in a reference population of patients without colorectal cancer. Our data can assist in the interpretation of <jats:styled-content style=\"fixed-case\">LARS<\/jats:styled-content> in past and future research about abdominal complaints after colorectal cancer surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.14790","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T17:28:50Z","timestamp":1564075730000},"page":"46-52","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["The low anterior resection syndrome in a reference population: prevalence and predictive factors in the Netherlands"],"prefix":"10.1111","volume":"22","author":[{"given":"M.","family":"van Heinsbergen","sequence":"first","affiliation":[{"name":"Department of Surgery VieCuri Medical Centre Venlo The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A. G.","family":"Van der Heijden","sequence":"additional","affiliation":[{"name":"Department of Surgery Maxima Medical Centre Veldhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. P.","family":"Stassen","sequence":"additional","affiliation":[{"name":"Department of Surgery Maastricht University Medical Centre+\/Uniklinik Aachen Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Melenhorst","sequence":"additional","affiliation":[{"name":"Department of Surgery Maastricht University Medical Centre+\/Uniklinik Aachen Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"de Witte","sequence":"additional","affiliation":[{"name":"Department of Surgery Zuyderland Medical Centre Sittard\u2010Geleen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. H.","family":"Belgers","sequence":"additional","affiliation":[{"name":"Department of Surgery Zuyderland Medical Centre Sittard\u2010Geleen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. J. G.","family":"Maaskant\u2010Braat","sequence":"additional","affiliation":[{"name":"Department of Surgery Maxima Medical Centre Veldhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. G.","family":"Bloemen","sequence":"additional","affiliation":[{"name":"Department of Surgery Catharina Hospital Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. D.","family":"Bouvy","sequence":"additional","affiliation":[{"name":"Department of Surgery Maastricht University Medical Centre+\/Uniklinik Aachen Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. L.","family":"Janssen\u2010Heijnen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology VieCuri Medical Centre Venlo The Netherlands"},{"name":"Department of Epidemiology GROW School for Oncology and Developmental Biology Maastricht University Medical Centre+ Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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