{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T15:56:11Z","timestamp":1772207771103,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,10,20]],"date-time":"2019-10-20T00:00:00Z","timestamp":1571529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim was to compare the pathological complete response (pCR) rate at 8 compared to 12\u00a0weeks\u2019 interval between completion of neoadjuvant chemoradiotherapy (CRT) and surgery in patients with locally advanced rectal cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This was a randomized trial which included a total of 330 patients from two institutions. Patients with locally advanced (T3\u20104N0M0, TxN+M0) rectal cancer were randomized into 8\u2010 and 12\u2010week interval groups. All the patients received long\u2010course CRT (45\u00a0Gy in 1.8\u00a0Gy fractions and concomitant oral capecitabine or 5\u2010fluorouracil infusion). Surgery was performed at either 8 or 12\u00a0weeks after CRT. The primary end\u2010point was pCR. Secondary end\u2010points were sphincter preservation, postoperative morbidity and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two\u2010hundred and fifty\u2010two patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0125 in the 8\u2010week group,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0127 in the 12\u2010week group) were included. Demographic and clinical characteristics were similar between groups. The overall pCR rate was 17.9% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a045): 12% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a015) in the 8\u2010week group and 23.6% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a030) in the 12\u2010week group (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.021). Sphincter\u2010preserving surgery was performed in 107 (85.6%) patients which was significantly higher than the 94 (74%) patients in the 12\u2010week group (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.016). Postoperative mortality was seen in three (1.2%) patients overall and was not different between groups (1.6% in 8\u00a0weeks\n                      <jats:italic>vs<\/jats:italic>\n                      0.8% in 12\u00a0weeks,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.494). Groups were similar in anastomotic leak (10.8% in 8\u00a0weeks\n                      <jats:italic>vs<\/jats:italic>\n                      4.5% in 12\u00a0weeks,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.088) and morbidity (30.4% in 8\u00a0weeks and 20.1% in 12\u00a0weeks,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.083).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Extending the interval between CRT and surgery from 8 to 12\u00a0weeks resulted in a 2\u2010fold increase in pCR rate without any difference in mortality and morbidity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.14867","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:11:11Z","timestamp":1569888671000},"page":"279-288","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Randomized controlled trial of 8 weeks\u2019\n                    <i>vs<\/i>\n                    12 weeks\u2019 interval between neoadjuvant chemoradiotherapy and surgery for locally advanced rectal cancer"],"prefix":"10.1111","volume":"22","author":[{"given":"C.","family":"Terzi","sequence":"first","affiliation":[{"name":"Department of General Surgery Dokuz Eylul University Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bingul","sequence":"additional","affiliation":[{"name":"Department of General Surgery Dokuz Eylul University Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2282-7207","authenticated-orcid":false,"given":"N. C.","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of General Surgery Medipol University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Department of General Surgery Uludag University Hospital Bursa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. E.","family":"Canda","sequence":"additional","affiliation":[{"name":"Department of General Surgery Dokuz Eylul University Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Isik","sequence":"additional","affiliation":[{"name":"Department of General Surgery Uludag University Hospital Bursa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Yilmazlar","sequence":"additional","affiliation":[{"name":"Department of General Surgery Uludag University Hospital Bursa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Obuz","sequence":"additional","affiliation":[{"name":"Department of Radiology Dokuz Eylul University Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Birkay Gorken","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Dokuz Eylul University Izmir 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