{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T17:10:10Z","timestamp":1765041010387,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T00:00:00Z","timestamp":1580169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Colectomy in patients with adenomatous polyposis (AP) syndromes demands good oncological and surgical outcome. Total colectomy with ileorectal anastomosis (TC\u2010IRA) is one surgical option for these patients. Anastomotic leakage rates of 11% have been reported following TC\u2010IRA. Ileo\u2010distal sigmoid anastomosis (IDSA) is a recent modification of our practice. Our aim was to compare postoperative outcome in patients with AP following near\u2010total colectomy with IDSA (NT\u2010IDSA) and TC\u2010IRA at a single institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A prospectively maintained database was reviewed to identify patients with AP who underwent laparoscopic NT\u2010IDSA and TC\u2010IRA. Patient demographics, early morbidity and mortality and outcome of endoscopic surveillance were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 191 patients with AP underwent laparoscopic colectomy between 2006 and 2017, of whom 139 (72.8%) underwent TC\u2010IRA and 52 (27.2%) NT\u2010IDSA. The median age at surgery in the TC\u2010IRA and NT\u2010IDSA groups was 20\u00a0years (IQR 17\u201345) and 27\u00a0years (IQR 19\u201350), respectively. Grade II complications were comparable between the two groups. There were no anastomotic leakages in the NT\u2010IDSA group compared with 15 (10.8%) in the TC\u2010IRA group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0125) and no reoperation in the NT\u2010IDSA group compared with 17 (12.2%) in the TC\u2010IRA group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.008). The frequency of polypectomies per flexible sigmoidoscopy was comparable between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrates that laparoscopic NT\u2010IDSA for polyposis is associated with a significant improvement in anastomotic leakage rates and surgical outcome. It is too soon to tell whether NT\u2010IDSA alters the need for further intervention, either endoscopic polypectomy or further surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.14964","type":"journal-article","created":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T06:56:35Z","timestamp":1578984995000},"page":"799-805","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Safety and efficacy of laparoscopic near\u2010total colectomy and ileo\u2010distal sigmoid anastomosis as a modification of total colectomy and ileorectal anastomosis for prophylactic surgery in patients with adenomatous polyposis syndromes: a comparative study"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0161-5141","authenticated-orcid":false,"given":"C. C.","family":"Anele","sequence":"first","affiliation":[{"name":"The Polyposis Registry St Mark\u2019s Hospital, London North West University Healthcare NHS Trust Harrow UK"},{"name":"Surgical Epidemiology, Trials and Outcome Centre (SETOC) St Mark\u2019s Hospital, London North West University Healthcare NHS Trust Harrow UK"},{"name":"Department of Surgery and Cancer Imperial College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Nachiappan","sequence":"additional","affiliation":[{"name":"Surgical Epidemiology, Trials and Outcome Centre (SETOC) St Mark\u2019s Hospital, London North West University Healthcare NHS Trust Harrow UK"},{"name":"Department of Surgery and Cancer Imperial College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Sinha","sequence":"additional","affiliation":[{"name":"The Polyposis Registry St Mark\u2019s Hospital, London North West University Healthcare NHS Trust Harrow UK"},{"name":"Department of Surgery and Cancer Imperial College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Cuthill","sequence":"additional","affiliation":[{"name":"The Polyposis Registry St Mark\u2019s Hospital, London North West University Healthcare NHS Trust Harrow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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