{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T18:30:35Z","timestamp":1778265035199,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T00:00:00Z","timestamp":1591228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to evaluate an association between colorectal neoplasm (CRN) and skeletal muscle mass using three widely accepted skeletal muscle mass indices (SMIs) in a large population at average risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We performed a cross\u2010sectional study using a screening colonoscopy database of 33 958 asymptomatic subjects aged 40\u201375\u00a0years. Appendicular skeletal muscle mass (ASM) was measured using a bioelectrical impedance analyser. ASM adjusted for height squared (ASM\/ht<jats:sup>2<\/jats:sup>), weight (ASM\/wt) and body mass index (ASM\/BMI) were used as indices for muscle mass. Logistic regression models were used to evaluate the association between SMIs and CRN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In a multivariable\u2010adjusted model, the risk of an advanced CRN increased linearly with decreasing quartiles for all three SMIs. The adjusted odds ratios (ORs) for advanced CRN in quartiles 1, 2 and 3 of ASM\/wt compared with that in quartile 4 were 1.279, 1.196 and 1.179, respectively (<jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub>\u00a0=\u00a00.017); for ASM\/BMI, ORs were 1.307, 1.144 and 1.091, respectively (<jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub>\u00a0=\u00a00.002); and for ASM\/ht<jats:sup>2<\/jats:sup>, ORs were 1.342, 1.169 and 1.062, respectively (<jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub>\u00a0=\u00a00.002). The risk of distally located advanced CRN was higher in quartile 1 than in quartile 4 for all three SMIs (ASM\/wt, OR = 1.356; ASM\/BMI, OR = 1.383; ASM\/ht<jats:sup>2<\/jats:sup>, OR = 1.430).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study demonstrated that low skeletal muscle mass was consistently associated with the presence of advanced CRN in a population at average risk regardless of the operational definition of the SMI, and it was particularly associated with distal advanced CRN.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.15103","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T07:35:02Z","timestamp":1588577702000},"page":"1293-1303","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of low skeletal muscle mass with the presence of advanced colorectal neoplasm: integrative analysis using three skeletal muscle mass indices"],"prefix":"10.1111","volume":"22","author":[{"given":"H. 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J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Health Screening and Promotion Center Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.\u2010K.","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Health Screening and Promotion Center Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Biostatistics Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.\u2010U.","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Health Screening and Promotion Center Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.\u2010S.","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Health Screening and Promotion Center Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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