{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T14:04:42Z","timestamp":1793196282836,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T00:00:00Z","timestamp":1592438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Fistula Laser Closure (FiLaC\u2122) is a novel sphincter\u2010preserving technique that is based on new technologies and shows promising results in repairing anal fistulas whilst maintaining external sphincter function. The aim of the present meta\u2010analysis is to present the efficacy and the safety of FiLaC\u2122 in the management of anal fistula disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>The present proportional meta\u2010analysis was designed using the PRISMA and AMSTAR guidelines. We searched MEDLINE, Scopus, clinicaltrials.gov, Embase, Cochrane Central Register of Controlled Trials CENTRAL and Google Scholar databases from inception until November 2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, eight studies were included that recruited 476 patients. The pooled success rate of the technique was 63% (95% CI 50%\u201375%). The pooled complication rate was 8% (95% CI 1%\u201318%). Sixty\u2010six per cent of patients had a transsphincteric fistula and 60% had undergone a previous surgical intervention, mainly the insertion of a seton (54%). The majority had a cryptoglandular fistula. Operation time and follow\u2010up period were described for each study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>FiLaC\u2122 seems to be an efficient therapeutic option for perianal fistula disease with an adequate level of safety that preserves quality of life. Nevertheless, randomized trials need to be designed to compare FiLaC\u2122 with other procedures for the management of anal fistulas such as ligation of intersphincteric fistula tract, anal advancement flaps, fibrin glue, collagen paste, autologous adipose tissue, fistula plug and video\u2010assisted anal fistula treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.15148","type":"journal-article","created":{"date-parts":[[2020,5,23]],"date-time":"2020-05-23T16:44:31Z","timestamp":1590252271000},"page":"1874-1884","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Could FiLaC\u2122 be effective in the treatment of anal fistulas? A systematic review of observational studies and proportional meta\u2010analysis"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9157-9860","authenticated-orcid":false,"given":"M.","family":"Frountzas","sequence":"first","affiliation":[{"name":"Laboratory of Experimental Surgery and Surgical Research School of Medicine National and Kapodistrian University of Athens Athens Greece"},{"name":"First Propaedeutic Department of Surgery School of Medicine Hippocration General Hospital National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Stergios","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Surgery and Surgical Research School of Medicine National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Nikolaou","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Surgery and Surgical Research School of Medicine National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Bellos","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Surgery and Surgical Research School of Medicine National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Schizas","sequence":"additional","affiliation":[{"name":"First Department of Surgery School of Medicine Laikon General Hospital National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Linardoutsos","sequence":"additional","affiliation":[{"name":"First Propaedeutic Department of Surgery School of Medicine Hippocration General Hospital National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Kontzoglou","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Surgery and Surgical Research School of Medicine National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Vaos","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery School of Medicine Attikon University General Hospital National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. B.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Guy's and St Thomas' NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Toutouzas","sequence":"additional","affiliation":[{"name":"First Propaedeutic Department of Surgery School of Medicine Hippocration General Hospital National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-017-1645-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1308\/rcsann.2016.0136"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-014-2104-7"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-019-01117-y"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviscsurg.2014.08.002"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000733"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000885"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2019.09.012"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i1.12"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-011-0726-0"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-015-1347-9"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2700"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j4008"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9491-z"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800630102"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v049.i05"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2006.04.004"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-135"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-016-1571-y"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2005.10.050"},{"key":"e_1_2_10_23_1","first-page":"142","article-title":"Closure of fistula tract with FiLaC [TM] laser as a sphincter\u2010preserving method in anal fistula treatment\/[Anal Fistul Tedavisinde Sfinkter Koruyucu Yontem Olarak FiLaC [TM] Lazer Yontemiyle Fistul Traktinin Kapatilmasi]","volume":"27","author":"Donmez T","year":"2017","journal-title":"Turkish J Colorectal Dis"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-015-1282-9"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.12440"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-018-1885-z"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-019-02077-9"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000067"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000001038"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-017-1599-7"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2005.10.050"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-014-1183-3"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-013-1050-7"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9518310"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2017.08.582"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-017-5905-2"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-019-02112-9"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2015.00055"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.13268"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000001093"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21836"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-015-1365-7"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-017-1621-0"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-017-1699-4"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surge.2016.02.002"},{"key":"e_1_2_10_46_1","unstructured":"TerranovaM TudiscaC CostanzoM ScopellitiL DiA PiazzaCGet al.Imaging assessment of perianal manifestations in Crohn's disease: tips and tricks. 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