{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:38:39Z","timestamp":1790163519739,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,6,14]],"date-time":"2020-06-14T00:00:00Z","timestamp":1592092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004097","name":"Fondation ARC pour la Recherche sur le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004097","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Transanal total mesorectal excision is a promising novel sphincter\u2010saving procedure for low rectal cancer. However, the transanal bottom\u2010up dissection is associated with increased rates of iatrogenic urethral injuries. Near\u2010infrared fluorescence (NIRF) imaging, given its deeper tissue penetration, has been explored in a limited number of studies for enhanced intra\u2010operative urethral visualization. In this study, we explored the feasibility of a novel, ultrabright, biocompatible fluorescent polymer to coat urinary catheters for the purpose of intra\u2010operative urethral visualization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In an <jats:italic>ex vivo<\/jats:italic> experiment, using a near\u2010infrared laparoscope, the fluorescent signal of a coated catheter (near\u2010infrared coating of equipment, NICE) was qualitatively and quantitatively compared to the signal of indocyanine green (ICG)\/Instillagel\u00ae mixtures and ICG\u2010filled catheters at several concentrations. Also, in three male human torsos, using fluorescent urinary catheters, NIRF\u2010guided perineal dissections and a transanal total mesorectal excision were performed. Intra\u2010operative NIRF\u2010based urethral visualization was performed systematically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the qualitative and quantitative fluorescence signal assessment, NICE\u2010coated catheters were clearly superior to the ICG\u2010based solutions. In the cadaveric experiments, enhanced urethral visualization was possible even at early stages of dissection, when the organ was covered by several tissue layers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>NICE\u2010coated catheters represent a promising potential to allow for NIRF\u2010based intra\u2010operative urethral visualization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.15156","type":"journal-article","created":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T21:35:45Z","timestamp":1590183345000},"page":"1749-1753","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A novel method for near\u2010infrared fluorescence imaging of the urethra during perineal and transanal surgery: demonstration in a cadaveric model"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8241-6442","authenticated-orcid":false,"given":"M.","family":"Barberio","sequence":"first","affiliation":[{"name":"IHU\u2010Strasbourg Institute of Image\u2010Guided Surgery Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Al\u2010Taher","sequence":"additional","affiliation":[{"name":"IHU\u2010Strasbourg Institute of Image\u2010Guided Surgery Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Forgione","sequence":"additional","affiliation":[{"name":"IHU\u2010Strasbourg Institute of Image\u2010Guided Surgery Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Hoskere Ashoka","sequence":"additional","affiliation":[{"name":"Laboratoire de Bio\u2010imagerie et Pathologies UMR 7021 CNRS Universit\u00e9 de Strasbourg Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Felli","sequence":"additional","affiliation":[{"name":"IHU\u2010Strasbourg Institute of Image\u2010Guided Surgery Strasbourg France"},{"name":"Institute of Physiology EA3072 Mitochondria Respiration and Oxidative Stress University of Strasbourg Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Agnus","sequence":"additional","affiliation":[{"name":"IHU\u2010Strasbourg Institute of Image\u2010Guided Surgery Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Marescaux","sequence":"additional","affiliation":[{"name":"IRCAD Research Institute against Digestive Cancer Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Klymchenko","sequence":"additional","affiliation":[{"name":"Laboratoire de Bio\u2010imagerie et Pathologies UMR 7021 CNRS Universit\u00e9 de Strasbourg 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