{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:54:01Z","timestamp":1747184041555,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,10,18]],"date-time":"2020-10-18T00:00:00Z","timestamp":1602979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000863","name":"Bowel Disease Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000863","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Randomized trials comparing surgical techniques for rectal prolapse are not always feasible. We assessed whether non\u2010randomized comparisons of those who have had surgery with those still waiting would be confounding baseline health status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This was a prospective cohort study in seven UK hospitals. Participants were \u2265\u00a018\u00a0years and listed for surgical interventions of equivalent intensity for rectal prolapse. They were defined as short or long waiters (\u2264 18 or &gt;\u00a018\u00a0weeks, respectively). Time on the waiting list was compared with baseline comorbidity (Charlson comorbidity index) and change from baseline in health status (EQ\u20105D\u20105L) at the time of surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 203 patients were analysed. Median (interquartile range) waiting time was 13.7\u00a0weeks (8.1, 20.4) varying across sites. Baseline comorbidity was not an important predictor of waiting time. Median Charlson comorbidity index was 2 (0, 3) for short and 1 (0, 3) for long waiters. A change in waiting time by a week was associated with negligible improvement in the EQ\u20105D\u20105L index of 0.001 (95% CI \u22120.000 to 0.003, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.106).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Negligible change in patient reported health status while on the waiting list and lack of effect of comorbidities in influencing waiting time support the use of non\u2010randomized pre\u2010\/post\u2010studies to compare the effects of surgical interventions for rectal prolapse.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.15293","type":"journal-article","created":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T19:39:46Z","timestamp":1596656386000},"page":"2170-2180","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Non\u2010randomized studies should be considered for assessing surgical techniques in rectal prolapse: prospective cohort study"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9971-1635","authenticated-orcid":false,"given":"M. J.","family":"Lee","sequence":"first","affiliation":[{"name":"Academic Directorate of General Surgery Sheffield Teaching Hospitals NHS FT Northern General Hospital Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Dimairo","sequence":"additional","affiliation":[{"name":"Clinical Trials Research Unit ScHARR University of Sheffield Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Edwards","sequence":"additional","affiliation":[{"name":"ScHARR University of Sheffield Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J.","family":"Hawkins","sequence":"additional","affiliation":[{"name":"Academic Directorate of General Surgery Sheffield Teaching Hospitals NHS FT Northern General Hospital Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Hind","sequence":"additional","affiliation":[{"name":"Clinical Trials Research Unit ScHARR University of Sheffield Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. H.","family":"Knowles","sequence":"additional","affiliation":[{"name":"Pragmatic Clinical Trials Unit Queen Mary University of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Hooper","sequence":"additional","affiliation":[{"name":"Pragmatic Clinical Trials Unit Queen Mary University of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0980-2793","authenticated-orcid":false,"given":"S. R.","family":"Brown","sequence":"additional","affiliation":[{"name":"Academic Directorate of General Surgery Sheffield Teaching Hospitals NHS FT Northern General Hospital Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Waiter study collaborative","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61086-2"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-015-1358-6"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32572-7"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.12177"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61116-8"},{"key":"e_1_2_11_7_1","first-page":"171","volume-title":"Quasi\u2010Experiments: Interrupted Time\u2010Series Designs for Generalized Causal Inference","author":"Shadish WR","year":"2002"},{"volume-title":"Methods Guide for Effectiveness and Comparative Effectiveness Reviews [Internet]","year":"2008","author":"Norris S","key":"e_1_2_11_8_1"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040296"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_11_11_1","unstructured":"https:\/\/euroqol.org\/eq\u20105d\u2010instruments\/eq\u20105d\u20105l\u2010about\/(accessed May 2019)."},{"key":"e_1_2_11_12_1","unstructured":"https:\/\/www.england.nhs.uk\/wp\u2010content\/uploads\/2015\/03\/delivering\u2010cancer\u2010wait\u2010times.pdf(accessed May 2019)."},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1258\/jrsm.2009.090044"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hec.3564"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.13117"},{"key":"e_1_2_11_16_1","doi-asserted-by":"crossref","first-page":"657","DOI":"10.47102\/annals-acadmedsg.V42N12p657","article-title":"What factors really matter? 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