{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T15:48:17Z","timestamp":1751384897162,"version":"3.40.5"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T00:00:00Z","timestamp":1599436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["PB\u2010PG\u20101217\u201020015"],"award-info":[{"award-number":["PB\u2010PG\u20101217\u201020015"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Atrial fibrillation (AF) is a common cardiac arrhythmia, and is associated with worsening quality of life and complications such as stroke. Previous work showed that 8% of patients develop new\u2010onset AF following colonic resection and highlighted factors that might predict the development of postoperative AF. The development of a new arrhythmia may have a negative effect on longer\u2010term quality of life as well as cancer survivorship. The aim of this study is to accurately quantify the incidence of AF following colorectal cancer surgery and to validate a model to predict its development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The Atrial Fibrillation After Resection (AFAR) study will recruit 720 patients aged 65 or over undergoing resection of colorectal cancer with curative intent. The primary outcome is development of AF within 90\u00a0days of surgery. Assessment of cardiac rhythm will be performed using 24\u2010h Holter monitors at baseline, 30 and 90\u00a0days after surgery. An electrocardiogram (ECG) will be performed on the day of discharge. Baseline descriptors including model variables and quality of life will be recorded using EQ\u20105D\u20105L. The occurrence of complications and other key surgical outcomes will be recorded. An additional blood test for N\u2010terminal pro B\u2010type natriuretic peptide (NT\u2010proBNP) will be performed prior to surgery. Statistical analysis will validate a previously derived model and will test the incremental value of added variables such as NT\u2010proBNP. Finally, an exploratory analysis will assess whether changes in ECG measures between baseline and postoperative ECG can predict subsequent new\u2010onset AF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study will provide data that may allow us to stratify the risk of developing AF following colorectal cancer surgery. This may inform screening or prophylactic approaches.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.15314","type":"journal-article","created":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T07:07:42Z","timestamp":1597475262000},"page":"307-315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Atrial fibrillation after resection: a PROGRESS III study"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9971-1635","authenticated-orcid":false,"given":"M. J.","family":"Lee","sequence":"first","affiliation":[{"name":"General Surgery Sheffield Teaching Hospitals NHS Foundation Trust Sheffield UK"},{"name":"Department of Oncology and Metabolism The Medical School University of Sheffield Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J.","family":"Hawkins","sequence":"additional","affiliation":[{"name":"General Surgery Sheffield Teaching Hospitals NHS Foundation Trust Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Bradburn","sequence":"additional","affiliation":[{"name":"Clinical Trials Research Unit University of Sheffield Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sheffield Teaching Hospitals NHS Foundation Trust Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0980-2793","authenticated-orcid":false,"given":"S. R.","family":"Brown","sequence":"additional","affiliation":[{"name":"General Surgery Sheffield Teaching Hospitals NHS Foundation Trust Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Wilson","sequence":"additional","affiliation":[{"name":"School of Health and Related Research Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1093\/eurheartj\/ehz431","article-title":"Risk of stroke and other adverse outcomes in patients with perioperative atrial fibrillation 1 year after non\u2010cardiac surgery","volume":"1","author":"Conen D","year":"2020","journal-title":"Eur Heart J"},{"key":"e_1_2_6_3_1","first-page":"CD013438","article-title":"Perioperative beta\u2010blockers for preventing surgery\u2010related mortality and morbidity in adults undergoing non\u2010cardiac surgery","volume":"9","author":"Domanovits H","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"doi-asserted-by":"publisher","key":"e_1_2_6_4_1","DOI":"10.1016\/j.jss.2019.01.017"},{"doi-asserted-by":"publisher","key":"e_1_2_6_5_1","DOI":"10.1371\/journal.pmed.1001380"},{"doi-asserted-by":"publisher","key":"e_1_2_6_6_1","DOI":"10.1371\/journal.pmed.1001381"},{"doi-asserted-by":"publisher","key":"e_1_2_6_7_1","DOI":"10.1002\/sim.6787"},{"doi-asserted-by":"publisher","key":"e_1_2_6_8_1","DOI":"10.1016\/j.jbi.2008.08.010"},{"doi-asserted-by":"publisher","key":"e_1_2_6_9_1","DOI":"10.1002\/bjs.9736"},{"doi-asserted-by":"publisher","key":"e_1_2_6_10_1","DOI":"10.1258\/0007142001903201"},{"doi-asserted-by":"publisher","key":"e_1_2_6_11_1","DOI":"10.1160\/TH14-03-0231"},{"doi-asserted-by":"publisher","key":"e_1_2_6_12_1","DOI":"10.1093\/jnci\/djy176"},{"doi-asserted-by":"publisher","key":"e_1_2_6_13_1","DOI":"10.1001\/jamacardio.2017.3180"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.15314","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.15314","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/codi.15314","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.15314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T16:47:25Z","timestamp":1693759645000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.15314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,7]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/codi.15314"],"URL":"https:\/\/doi.org\/10.1111\/codi.15314","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"type":"print","value":"1462-8910"},{"type":"electronic","value":"1463-1318"}],"subject":[],"published":{"date-parts":[[2020,9,7]]},"assertion":[{"value":"2020-05-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}