{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:10:09Z","timestamp":1790403009950,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Women with a history of human papillomavirus (HPV)\u2010related cervical, vaginal or vulvar high\u2010grade squamous intra\u2010epithelial lesions (HSILs) or cancer are at increased risk of developing anal squamous intra\u2010epithelial lesions (SILs) or a squamous cell carcinoma of the anus (SCCA). Screening for intra\u2010anal SILs with high\u2010resolution anoscopy (HRA) in high\u2010risk populations is a subject of debate. In this study we aimed to answer the following question: what is the prevalence of intra\u2010anal (H)SIL in women with HPV\u2010related vulvar and\/or perianal disease using HRA for screening?<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A retrospective study was performed to evaluate the prevalence of intra\u2010anal (H)SIL in women with a history of vulvar and\/or perianal HSIL or (superficially invasive) squamous cell carcinoma (SCC). This study was performed between 2015 and 2018 following implementation of a protocol for intra\u2010anal screening using HRA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010seven patients, 10 with a history of (superficially invasive) SCC (four vulvar, five perianal, one multizonal) and 17 with HSIL as the worst diagnosis (two perianal, 15 multizonal) were screened for intra\u2010anal lesions using HRA. No anal cancer was found at screening, 6 (22%) patients were diagnosed with intra\u2010anal HSIL and 12 (44%) patients with intra\u2010anal low\u2010grade SIL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found a high prevalence of intra\u2010anal HSIL in women previously diagnosed with vulvar and perianal HSIL. Given the clear link between HSIL and SCCA, screening for intra\u2010anal lesions in women with HPV\u2010related genital pathology seems warranted. Future studies should focus on the effect of HSIL treatment on the prevention of anal cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.15320","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T12:36:44Z","timestamp":1598618204000},"page":"1991-1998","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Screening for intra\u2010anal squamous intra\u2010epithelial lesions in women with a history of human papillomavirus\u2010related vulvar or perianal disease: results of a screening protocol"],"prefix":"10.1111","volume":"22","author":[{"given":"K.","family":"Leber","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Amsterdam UMC \u2013 location AMC Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"van Beurden","sequence":"additional","affiliation":[{"name":"Department of Gynaecology The Netherlands Cancer Institute Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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