{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T17:29:25Z","timestamp":1770226165517,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T00:00:00Z","timestamp":1599177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Crohn's disease (CD)\u2010related rectovaginal fistulas (RVFs) are rare, challenging to treat and associated with a high morbidity. Due to a significant lack of data, we aimed to analyse the safety and feasibility of allogeneic adipose\u2010derived stem cells (ASCs) in the treatment of CD\u2010related RVF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Four consecutive patients with CD\u2010related RVF underwent treatment with expanded allogeneic ASCs extracted from a healthy donor in a tertiary referral centre in 2019. None of the patients had an intestinal diversion at the time of the treatment. Follow\u2010up was performed 6\u00a0months postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median operation time was 45\u00a0min with a median hospital stay of 3\u00a0days. No intra\u2010operative complications occurred. Three patients (75%) developed recurrent RVF after a median follow\u2010up of 19\u00a0days. Two patients required surgical treatment including loose seton drainage due to discharge and pain. One patient developed recurrence of symptoms after 10\u00a0days, but refused further surgical therapy. Only one patient (25%) showed healing of the RVF, with re\u2010epithelialization of both the vaginal and rectal opening and absence of clinical symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Expanded allogeneic ASC therapy represents a novel safe treatment option for CD\u2010associated RVF. Although efficacy appears limited, further controlled studies are required to draw robust conclusions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.15324","type":"journal-article","created":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T10:52:14Z","timestamp":1598266334000},"page":"153-158","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Allogeneic expanded adipose\u2010derived stem cells in the treatment of rectovaginal fistulas in Crohn\u2019s disease"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4003-2491","authenticated-orcid":false,"given":"M.","family":"Nikolic","sequence":"first","affiliation":[{"name":"Department of Surgery Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Stift","sequence":"additional","affiliation":[{"name":"Department of Surgery Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Reinisch","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Vogelsang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Matic","sequence":"additional","affiliation":[{"name":"Department of Surgery Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Surgery Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"von Strauss und Torney","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery St Clara Hospital and University Hospital Basel Clarunis University Centre for Gastrointestinal and Liver Diseases Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Riss","sequence":"additional","affiliation":[{"name":"Department of Surgery Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,4]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"Doc15","article-title":"German S3\u2010Guideline: rectovaginal fistula","volume":"10","author":"Ommer A","year":"2012","journal-title":"Ger Med Sci"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.4240\/wjgs.v7.i8.133"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1687834"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izz215"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjy195"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1683908"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-017-1739-0"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5298214"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e318255364a"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.8.9.1417"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181973487"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6132340"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2015-0356"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2009.07.010"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05409.x"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-005-0052-6"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.12.020"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(76)80163-1"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastro.2003.08.025"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13304-018-0558-9"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2018170167"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-018-1918-7"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.4174\/astr.2019.97.3.149"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6661"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.15324","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/codi.15324","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.15324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T16:47:11Z","timestamp":1693759631000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.15324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,4]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/codi.15324"],"URL":"https:\/\/doi.org\/10.1111\/codi.15324","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,4]]},"assertion":[{"value":"2020-05-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}