{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T01:17:16Z","timestamp":1784251036318,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T00:00:00Z","timestamp":1610323200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Failure of primary ileal pouch\u2013anal anastomosis (IPAA) occurs in up to 15% of patients. Revision surgery may be offered to patients wishing to maintain gastrointestinal continuity. This paper explores the literature relating to IPAA revision surgery, focusing on pouch function after revision and factors associated with pouch failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Search of PubMed database was carried out for \u2018ileal pouch anal anastomoses\u2019, \u2018ileoanal pouch\u2019, \u2018restorative proctocolectomy\u2019, \u2018revision surgery\u2019, \u2018redo surgery\u2019, \u2018failure\u2019, \u2018refashion surgery\u2019, \u2018reconstruction surgery\u2019 and \u2018salvage surgery\u2019. Papers were screened using the PRISMA literature review strategy. Studies of adults published after 1980 in English with an available abstract were included. Case reports and studies that were superseded using the same data were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nineteen papers (1424 patients) were identified. Bowel motion frequency doubled following revision surgery compared to primary IPAA although the increase was not always statistically significant. In patients failing primary IPAA, frequency of daytime bowel motions improved following revision in three studies but only reached significance in one (12.1 vs. 6.9, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.021). Risk of pouch failure is increased in patients who develop pelvic sepsis after the primary procedure with the largest study demonstrating a four\u2010fold increased risk (hazard ratio 3.691, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). A final diagnosis of Crohn's causes a four\u2010fold increased risk of pouch failure (<jats:italic>n<\/jats:italic>\u00a0=\u00a081; OR 3.92, 95% CI 1.1\u201315.9, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients undergoing revisional surgery, improved outcomes are observed but are inferior compared to primary IPAA patients. Pelvic sepsis after primary IPAA and a final diagnosis of Crohn's are associated with increased risk of pouch failure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.15418","type":"journal-article","created":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T16:45:55Z","timestamp":1604162755000},"page":"52-63","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Revisional ileoanal pouch surgery: a systematic literature review assessing outcomes over the last 40\u00a0years"],"prefix":"10.1111","volume":"23","author":[{"given":"Holly","family":"Carpenter","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery Whipps Cross Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Hotouras","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Whipps Cross Hospital London UK"},{"name":"National Bowel Research Centre Blizard Institute QMUL London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6674-3446","authenticated-orcid":false,"given":"William J.","family":"English","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Whipps Cross Hospital London UK"},{"name":"National Bowel Research Centre Blizard Institute QMUL London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona G. M.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Whipps Cross Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Andreani","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Whipps Cross Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e31819eef8f"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001386"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000537"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2014.10.016"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2017.11.011"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjv066"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000001130"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181b77d1e"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5242"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000364837"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31819a697b"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4973"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-6747-2"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-6321-y"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02055376"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000094"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000330"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000001313"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2018.08.004"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.13587"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(00)00523-7"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1091-255X(99)80086-9"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199902000-00006"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.15418","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/codi.15418","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.15418","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T16:48:18Z","timestamp":1693759698000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.15418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/codi.15418"],"URL":"https:\/\/doi.org\/10.1111\/codi.15418","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2020-05-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}