{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T23:44:39Z","timestamp":1783035879797,"version":"3.54.6"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T00:00:00Z","timestamp":1607990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this work was to estimate the prevalence of iron deficiency in patients diagnosed with colorectal cancer (CRC) and to clarify its association with patient\u2010 and tumour\u2010related characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This was a single\u2010centre registry\u2010based cohort study. Iron status was routinely evaluated upon diagnosis of CRC, and these data were coupled with patient\u2010 and tumour\u2010specific data from the Danish CRC Group Registry (2013\u20132018). Data were analysed using multivariate logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 846 patients, 543 (64%) were iron deficient. There was an association between increasing depth of invasion and iron deficiency, with odds ratios (ORs) of iron deficiency being 2.8 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001, CI 1.5\u20135.1), 4.22 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001, CI 2.48\u20137.18) and 4.63 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001, CI 2.30\u20139.34) for T\u2010stages 2, 3 and 4, respectively. Right\u2010sided tumours had an OR of 3.54 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001, CI 2.22\u20135.67) of iron deficiency compared with left\u2010sided tumours. Tumours diagnosed through the national CRC screening programme were less likely to be associated with iron deficiency (OR 0.34, CI 0.22\u20130.52), while female gender was associated with an increase in the odds for iron deficiency (OR 1.91, CI 1.33\u20132.76). Iron deficiency was prevalent in 88% of anaemic patients and 43% of nonanaemic patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Iron deficiency was highly prevalent in patients diagnosed with CRC. Increased depth of tumour invasion, right\u2010sided location and female gender were all associated with higher odds for iron deficiency, while patients diagnosed through the national screening programme were associated with lower odds for iron deficiency. A large proportion of patients with a normal haemoglobin were also iron deficient.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.15467","type":"journal-article","created":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T20:00:27Z","timestamp":1606766427000},"page":"853-859","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Iron deficiency in colorectal cancer patients: a cohort study on prevalence and associations"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4229-3994","authenticated-orcid":false,"given":"Magnus","family":"Ploug","sequence":"first","affiliation":[{"name":"Department of Surgical Gastroenterology Hospital of South West Jutland Esbjerg Denmark"},{"name":"Department of Regional Health Research University of Southern Denmark Odense Denmark"},{"name":"OPEN, Open Patient Data Explorative Network Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasmus","family":"Kroijer","sequence":"additional","affiliation":[{"name":"Department of Surgical Gastroenterology Hospital of South West Jutland Esbjerg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Qvist","sequence":"additional","affiliation":[{"name":"Research Unit for Surgery Odense University Hospital Odense Denmark"},{"name":"University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte Hass","family":"Lindahl","sequence":"additional","affiliation":[{"name":"Department of Surgical Gastroenterology Hospital of South West Jutland Esbjerg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torben","family":"Knudsen","sequence":"additional","affiliation":[{"name":"Department of Regional Health Research University of Southern Denmark Odense Denmark"},{"name":"Department of Medical Gastroenterology Hospital of South West Jutland Esbjerg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14278"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14456"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt118"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-196904000-00005"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005350050120"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2016.12.029"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-017-2898-1"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-016-2678-3"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603439"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.14425"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.22032"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607188012003282"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-015-2461-x"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313480206800614"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2019.17770"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3747\/co.26.4983"},{"key":"e_1_2_12_18_1","first-page":"713","article-title":"Prevalence of anaemia at diagnosis of colorectal cancer: assessment of associated risk factors","volume":"59","author":"Edna T\u2010H","year":"2012","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2015.12.052"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i8.1972"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-018-3125-2"},{"key":"e_1_2_12_22_1","unstructured":"DCCG Yearly Report;2017. 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