{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:05:44Z","timestamp":1787317544130,"version":"build-2736575974"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T00:00:00Z","timestamp":1609200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The treatment of perianal fistulas in Crohn's disease remains challenging. Fibrin glue injection has previously shown short\u2010term efficacy in a randomized controlled trial. No long\u2010term data are available to assess the benefit of this treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective multicentre study included all patients with drained fistulas treated by at least one fibrin glue injection between January 2004 and June 2015 in three tertiary French centres. The primary end\u2010point was the rate of complete clinical remission at 1\u00a0year after injection defined by the closure of all fistula tracts with no need for iterative anal surgery or for optimization of immunosuppressants and\/or biologics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In all, 119 patients (median age 33\u00a0years, complex fistulas 65%, median previous anal surgery two, median Harvey Bradshaw score 3, immunosuppressants exposure 50%, anti\u2010tumor necrosis factor exposure 60% with median time of administration of 1.1\u00a0year) were analysed with a median follow\u2010up of 18.3\u00a0months. The complete clinical remission rate at 1\u00a0year was 45.4%. The primary end\u2010point was achieved in 63% of the cases in the combination therapy group and 37% in other patients. The only predictor of complete clinical remission at 1 year was combination therapy at the time of injection (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.01). The rate of early reintervention after glue injection was 2.5%. The cumulative incidence of iterative anal surgery and ostomy in the whole population was 54% and 5.6% respectively at 5 years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>An adjunct of fibrin glue to conventional medical therapy may be an effective and safe treatment for perianal fistulas in patients with Crohn's disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.15477","type":"journal-article","created":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T19:25:54Z","timestamp":1607196354000},"page":"894-900","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Long\u2010term efficacy of fibrin glue injection for perianal fistulas in patients with Crohn's disease"],"prefix":"10.1111","volume":"23","author":[{"given":"Mathias","family":"Vidon","sequence":"first","affiliation":[{"name":"Service de Gastroent\u00e9rologie H\u00f4pital Saint\u2010Louis Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Munoz\u2010Bongrand","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Digestive H\u00f4pital Saint\u2010Louis Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Lambert","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2014Denis Diderot Paris France"},{"name":"Service de Biostatistiques H\u00f4pital Saint\u2010Louis Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9on","family":"Maggiori","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2014Denis Diderot Paris France"},{"name":"Service de Chirurgie Digestive H\u00f4pital Beaujon Clichy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010David","family":"Zeitoun","sequence":"additional","affiliation":[{"name":"Service de Proctologie Groupe Hospitalier Diaconesses\u2010Croix Saint\u2010Simon Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Corte","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Digestive H\u00f4pital Saint\u2010Louis Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Panis","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2014Denis Diderot Paris France"},{"name":"Service de Chirurgie Digestive H\u00f4pital Beaujon Clichy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Seksik","sequence":"additional","affiliation":[{"name":"Service de Gastroent\u00e9rologie et Nutrition APHP H\u00f4pital Saint\u2010Antoine Sorbonne Universit\u00e9 Paris France"},{"name":"Universit\u00e9 Sorbonne\u2010UPMC Paris VI Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Treton","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2014Denis Diderot Paris France"},{"name":"Service de Gastroent\u00e9rologie H\u00f4pital Beaujon Clichy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Abramowitz","sequence":"additional","affiliation":[{"name":"Proctologie du service de Gastroent\u00e9rologie H\u00f4pital Bichat Clinique Blomet Groupe Ramsay g\u00e9n\u00e9rale de sant\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Allez","sequence":"additional","affiliation":[{"name":"Service de Gastroent\u00e9rologie H\u00f4pital Saint\u2010Louis Paris France"},{"name":"Universit\u00e9 Paris\u2014Denis Diderot Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Marc","family":"Gornet","sequence":"additional","affiliation":[{"name":"Service de Gastroent\u00e9rologie H\u00f4pital Saint\u2010Louis Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.32362"},{"key":"e_1_2_9_3_1","unstructured":"BouchardD AbramowitzL BouguenG BrochardC De ParadesV DabadieAet al.Recommandations pour la pratique clinique dans les l\u00e9sions anop\u00e9rin\u00e9ales de Crohn. 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