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Clearly defining acute obstruction is important for design and interpretation of studies as well as for guidelines and daily practice. This systematic review aimed to evaluate definitions of obstruction by colorectal cancer in prospective studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A systematic search was performed in PubMed, Embase and the Cochrane Library. Eligibility criteria included randomized or prospective observational design, publication between 2000 and 2019, and the inclusion of patients with an obstruction caused by colorectal cancer. Provided definitions of obstruction were extracted with assessment of common elements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 16 randomized controlled trials (RCTs) and 99 prospective observational studies were included. Obstruction was specified as acute in 28 studies, complete\/emergency in five, (sub)acute or similar terms in four and unspecified in 78. Five of 16 RCTs (31%) and 37 of 99 cohort studies (37%) provided a definition. The definitions included any combination of clinical symptoms, physical signs, endoscopic features and radiological imaging findings in 25 studies. The definition was only based on clinical symptoms in 11 and radiological imaging in six studies. Definitions included a radiological component in 100% of evaluable RCTs (5\/5) vs. 54% of prospective observational studies (20\/37, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.07).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this systematic review, the majority of prospective studies did not define obstruction by colorectal cancer and its urgency, whereas provided definitions varied hugely. Radiological confirmation seems to be an essential component in defining acute obstruction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.15479","type":"journal-article","created":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T09:01:47Z","timestamp":1607677307000},"page":"787-804","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Definition of large bowel obstruction by primary colorectal cancer: A systematic review"],"prefix":"10.1111","volume":"23","author":[{"given":"Joyce V.","family":"Veld","sequence":"first","affiliation":[{"name":"Department of Surgery Cancer Center Amsterdam Amsterdam UMC University of Amsterdam Amsterdam The Netherlands"},{"name":"Department of Gastroenterology and Hepatology Cancer Center Amsterdam Amsterdam UMC University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim J.","family":"Beek","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology NWZ Alkmaar Alkmaar The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther C.J.","family":"Consten","sequence":"additional","affiliation":[{"name":"Department of Surgery Meander Medical Center Amersfoort The Netherlands"},{"name":"Department of Surgery University Medical Center Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"ter Borg","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Deventer Hospital Deventer The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henderik L.","family":"van Westreenen","sequence":"additional","affiliation":[{"name":"Department of Surgery Isala Zwolle Zwolle The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilhelmus A.","family":"Bemelman","sequence":"additional","affiliation":[{"name":"Department of Surgery Cancer Center Amsterdam Amsterdam UMC University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanin E.","family":"van Hooft","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Cancer Center Amsterdam Amsterdam UMC University of Amsterdam Amsterdam The Netherlands"},{"name":"Department of Gastroenterology and Hepatology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3146-3310","authenticated-orcid":false,"given":"Pieter J.","family":"Tanis","sequence":"additional","affiliation":[{"name":"Department of Surgery Cancer Center Amsterdam Amsterdam UMC University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2010.02191.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1140-3017"},{"key":"e_1_2_10_4_1","unstructured":"Group JCSSPR.CROSS: ColoRectal Obstruction Scoring System 2012. 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