{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:50:21Z","timestamp":1747198221744,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,1,3]],"date-time":"2021-01-03T00:00:00Z","timestamp":1609632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Conventional parameters (anal resting and squeeze pressures) measured with anorectal manometry (ARM) fail to identify anal sphincter dysfunction in many patients with low anterior resection syndrome (LARS). We aimed to assess whether there are differences in anal canal slow\u2010wave pressure activity in LARS patients and healthy individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>High\u2010resolution ARM (HR\u2010ARM) traces of 21 consecutive male LARS patients referred to the Royal London Hospital, UK (<jats:italic>n<\/jats:italic>\u00a0=\u00a012) and Aarhus University Hospital, Denmark (<jats:italic>n<\/jats:italic>\u00a0=\u00a09) were compared with HR\u2010ARM data from 37 healthy men.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Qualitatively (by visual inspection of HR\u2010ARM recordings), the frequency of slow\u2010wave pressure activity was strikingly different in 11\/21 (52.4%) LARS patients from that observed in all the healthy individuals. Quantitative analysis showed that peaks of the mean spectrum in these 11 LARS patients occurred at approximately 6\u20137 cycles per minute (cpm), without activity at higher frequencies. An equivalent pattern was found in only 2\/37 (5.4%) healthy individuals (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). Peaks of the mean spectrum in healthy individuals were concentrated at 16\u00a0cpm and 3\u20134\u00a0cpm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Over half of the male LARS patients studied had altered anal slow\u2010wave pressure activity based on analysis of HR\u2010ARM recordings. Further studies could investigate the relative contributions of sex, human baseline variance and neoadjuvant\/surgical therapies on anal slow waves, and correlate the presence of abnormal activity with symptom severity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.15502","type":"journal-article","created":{"date-parts":[[2020,12,20]],"date-time":"2020-12-20T18:26:25Z","timestamp":1608488785000},"page":"444-450","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Altered anal slow\u2010wave pressure activity in low anterior resection syndrome: short case series in two independent specialist centres provide new mechanistic insights"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3158-6652","authenticated-orcid":false,"given":"Paul F.","family":"Vollebregt","sequence":"first","affiliation":[{"name":"National Bowel Research Centre and GI Physiology Unit Blizard Institute Centre for Neuroscience, Surgery and Trauma Queen Mary University of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukasz","family":"Wiklendt","sequence":"additional","affiliation":[{"name":"College of Medicine and Public Health and Centre for Neuroscience, Flinders University Discipline of Surgery and Gastroenterology, Flinders Medical Centre Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daphne","family":"Ang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Changi General Hospital Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3015-7039","authenticated-orcid":false,"given":"Mary L.","family":"Venn","sequence":"additional","affiliation":[{"name":"National Bowel Research Centre and GI Physiology Unit Blizard Institute Centre for Neuroscience, Surgery and Trauma Queen Mary University of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mira","family":"Mekhael","sequence":"additional","affiliation":[{"name":"Department of Surgery Aarhus University Hospital Aarhus Denmark"},{"name":"Danish Cancer Society Centre for Research on Survivorship and Late Adverse Effects after Cancer in the Pelvic Organs Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Surgery Aarhus University Hospital Aarhus Denmark"},{"name":"Danish Cancer Society Centre for Research on Survivorship and Late Adverse Effects after Cancer in the Pelvic Organs Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phil G.","family":"Dinning","sequence":"additional","affiliation":[{"name":"College of Medicine and Public Health and Centre for Neuroscience, Flinders University Discipline of Surgery and Gastroenterology, Flinders Medical Centre Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles H.","family":"Knowles","sequence":"additional","affiliation":[{"name":"National Bowel Research Centre and GI Physiology Unit Blizard Institute Centre for Neuroscience, Surgery and Trauma Queen Mary University of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Mark","family":"Scott","sequence":"additional","affiliation":[{"name":"National Bowel Research Centre and GI Physiology Unit Blizard Institute Centre for Neuroscience, Surgery and Trauma Queen Mary University of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70236-X"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000495"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.14207"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90277-R"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm18172"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12858"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13679"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13532"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31824f1c21"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.44.1.77"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02056950"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00484"},{"key":"e_1_2_10_14_1","unstructured":"WiklendtL CostaM BrookesS DinningPG.Bayesian functional mixed\u2010effects model with Gaussian process responses for wavelet spectra of spatiotemporal colonic manometry signals. arXiv preprint arXiv:1912.02389 2019."},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02238016"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00341207"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.13942"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13871"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e31824154a0"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.15502","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/codi.15502","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.15502","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T00:54:58Z","timestamp":1693702498000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.15502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,3]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1111\/codi.15502"],"URL":"https:\/\/doi.org\/10.1111\/codi.15502","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"type":"print","value":"1462-8910"},{"type":"electronic","value":"1463-1318"}],"subject":[],"published":{"date-parts":[[2021,1,3]]},"assertion":[{"value":"2020-10-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}