{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:27:20Z","timestamp":1790360840466,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T00:00:00Z","timestamp":1612310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Crohn's disease is a chronic inflammatory bowel disease characterized by alternating periods of exacerbation and remission. Surgical resection is not curative and postoperative recurrence (POR) remains a challenge in these patients. The aim of this study was to identify clinical variables that influence the risk of symptomatic anastomotic POR in patients with ileo\u2010colonic Crohn's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A retrospective study of Crohn's disease patients who had undergone ileo\u2010colic resection between January 2014 and December 2018 was performed. For each patient, data including demographic information, Crohn's disease clinical setting, preoperative radiological data, operative and histological data, pre\u2010 and postoperative medication history and postoperative clinical course, including recurrence of disease, were extracted. Symptomatic anastomotic POR was defined as symptoms of Crohn's disease in the presence of confirmed anastomotic POR (endoscopic and\/or radiological POR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For the study period, 104 patients were eligible and included for analysis. The cumulative probability of symptomatic anastomotic POR was 14%, 30%, 42%, 50% and 50% at 1, 2, 3, 4 and 5\u00a0years, respectively. Two clinical variables on multivariate analysis were associated with increased risk of symptomatic anastomotic POR, namely age &lt;17\u00a0years at diagnosis [hazard ratio (HR) 2.17, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.019] and gastrointestinal involvement (extent) &gt;30\u00a0cm (HR 1.85, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.048).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study describes the natural history of POR after ileo\u2010colic resection for Crohn's disease, as defined by endoscopic, radiological and clinical outcomes. Age &lt;17\u00a0years at diagnosis and gastrointestinal involvement (extent) &gt;30\u00a0cm were independent risk factors for symptomatic anastomotic POR.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.15530","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T23:29:30Z","timestamp":1610753370000},"page":"1184-1192","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Risk factors for symptomatic anastomotic postoperative recurrence following ileo\u2010colic resection in Crohn\u2019s disease"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1939-0825","authenticated-orcid":false,"given":"Lalin","family":"Navaratne","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery Barts Health NHS Trust The Royal London Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine\u2010Helen","family":"Hurndall","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Barts Health NHS Trust The Royal London Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M.","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Barts Health NHS Trust The Royal London Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Stephenson","sequence":"additional","affiliation":[{"name":"Department of Radiology Barts Health NHS Trust The Royal London Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niall","family":"Power","sequence":"additional","affiliation":[{"name":"Department of Radiology Barts Health NHS Trust The Royal London Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly","family":"Gillott","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Barts Health NHS Trust The Royal London Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Ruiz S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology St George\u2019s University Hospitals NHS Foundation Trust St George\u2019s Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuresh","family":"Khodatars","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Barts Health NHS Trust The Royal London Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L. 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