{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:50:46Z","timestamp":1787320246599,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Patients with locally recurrent rectal cancer (LRRC) frequently present with either synchronous metastases or a history of metastases. This study was conducted to evaluate whether LRRC patients without metastases have a different oncological outcome compared to patients with a history of metastases treated with curative intent or patients with potentially curable synchronous metastases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>All consecutive LRRC patients who underwent intentionally curative surgery between 2005 and 2017 in a large tertiary hospital were retrospectively reviewed and categorized as having no metastases, a history of (curatively treated) metastases or synchronous metastases. Patients with unresectable distant metastases were excluded from the analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 349 patients who were analysed, 261 (75%) had no metastases, 42 (12%) had a history of metastases and 46 (13%) had synchronous metastases. The 3\u2010year metastasis\u2010free survival was 52%, 33% and 13% in patients without metastases, with a history of metastases, and with synchronous metastases, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) A history of metastases did not influence overall survival (OS), but there was a trend towards a worse OS in patients with synchronous metastases compared with patients without synchronous metastases (hazard ratio 1.43; 95% CI 0.98\u20132.11).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LRRC patients with a history of curatively treated metastases have an OS comparable to that in patients without metastases and should therefore be treated with curative intent. However, LRRC patients with synchronous metastases have a poor metastasis\u2010free survival and worse OS; in these patients, an individualized treatment approach to observe the behaviour of the disease is recommended.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.15537","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T03:57:15Z","timestamp":1611201435000},"page":"1120-1131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of a history of metastases or synchronous metastases on survival in patients with locally recurrent rectal cancer"],"prefix":"10.1111","volume":"23","author":[{"given":"E. L. K.","family":"Voogt","sequence":"first","affiliation":[{"name":"Department of Surgery Catharina Hospital Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. M. G. I.","family":"van Zoggel","sequence":"additional","affiliation":[{"name":"Department of Surgery Catharina Hospital Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kusters","sequence":"additional","affiliation":[{"name":"Department of Surgery Amsterdam University Medical Centres, Location VUmc Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. A. P.","family":"Nieuwenhuijzen","sequence":"additional","affiliation":[{"name":"Department of Surgery Catharina Hospital Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. S.","family":"Cnossen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Catharina Hospital Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. J.","family":"Creemers","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Catharina Hospital Eindhoven Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"van Lijnschoten","sequence":"additional","affiliation":[{"name":"Pathology Department PAMM Laboratory for Pathology and Medical Microbiology Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Nederend","sequence":"additional","affiliation":[{"name":"Department of Radiology Catharina Hospital Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Roef","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Catharina Hospital Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. W. A.","family":"Burger","sequence":"additional","affiliation":[{"name":"Department of Surgery Catharina Hospital Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. J. T.","family":"Rutten","sequence":"additional","affiliation":[{"name":"Department of Surgery Catharina Hospital Eindhoven The Netherlands"},{"name":"GROW School for Oncology and Developmental Biology Maastricht University Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw235"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt124"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.11418"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-008-9896-z"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000388"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9569"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2009.02167.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10694"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-020-08362-4"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.01.023"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2019.06.016"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2019.10.037"},{"key":"e_1_2_11_14_1","volume-title":"Madame Curie Bioscience Database","author":"Martin TA","year":"2000"},{"key":"e_1_2_11_15_1","first-page":"8","volume-title":"Madame Curie Bioscience Database","author":"Leong L","year":"2013"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20170134"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-008-0517-8"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2020.02.032"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2003.05.039"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-1218-6"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e318197939a"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e318279b743"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000145964.08365.01"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.15537","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/codi.15537","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.15537","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T08:09:42Z","timestamp":1693555782000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.15537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,18]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1111\/codi.15537"],"URL":"https:\/\/doi.org\/10.1111\/codi.15537","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,18]]},"assertion":[{"value":"2020-11-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}